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Cellosaurus PDIS-6 (CVCL_RN09)

[Text version]
Cell line name PDIS-6
Synonyms LN319/hPDPN-KO
Accession CVCL_RN09
Resource Identification Initiative To cite this cell line use: PDIS-6 (RRID:CVCL_RN09)
Comments Problematic cell line: Contaminated. Parent cell line (LN-319) has been shown to be a LN-992 derivative.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; 29602; PDPN.
Derived from site: In situ; Brain, right temporal lobe; UBERON=UBERON_0002809.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (from parent cell line).
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3958 (LN-319)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=27031228; DOI=10.1371/journal.pone.0152912
Kato Y., Ogasawara S., Oki H., Goichberg P., Honma R., Fujii Y., Kaneko M.K.
LpMab-12 established by CasMab technology specifically detects sialylated O-glycan on Thr52 of platelet aggregation-stimulating domain of human podoplanin.
PLoS ONE 11:E0152912-E0152912(2016)

PubMed=27328060; DOI=10.1089/mab.2016.0006
Ogasawara S., Kaneko M.K., Honma R., Oki H., Fujii Y., Takagi M., Suzuki H., Kato Y.
Establishment of mouse monoclonal antibody LpMab-13 against human podoplanin.
Monoclon. Antib. Immunodiagn. Immunother. 35:155-162(2016)

PubMed=27564251; DOI=10.1089/mab.2016.0031
Ogasawara S., Kaneko M.K., Kato Y.
LpMab-19 recognizes sialylated O-Glycan on Thr76 of human podoplanin.
Monoclon. Antib. Immunodiagn. Immunother. 35:245-253(2016)

PubMed=28101903; DOI=10.1002/cam4.954
Kaneko M.K., Nakamura T., Honma R., Ogasawara S., Fujii Y., Abe S., Takagi M., Harada H., Suzuki H., Nishioka Y., Kato Y.
Development and characterization of anti-glycopeptide monoclonal antibodies against human podoplanin, using glycan-deficient cell lines generated by CRISPR/Cas9 and TALEN.
Cancer Med. 6:382-396(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RN09
Encyclopedic resources Wikidata; Q54946849
Entry history
Entry creation05-Mar-2018
Last entry update30-Jan-2024
Version number8