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Cellosaurus COLO 357-TRS4 (CVCL_RL60)

[Text version]
Cell line name COLO 357-TRS4
Synonyms COLO-TRS4
Accession CVCL_RL60
Resource Identification Initiative To cite this cell line use: COLO 357-TRS4 (RRID:CVCL_RL60)
Comments Population: African American.
Characteristics: Expresses tetracyclin-inducible SMAD4 siRNA.
Knockout cell: Method=siRNA knockdown; HGNC; HGNC:6770; SMAD4.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Derived from site: Metastatic; Celiac axis lymph node; UBERON=UBERON_0002508.
Sequence variations
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (from parent cell line).
Disease Pancreatic adenosquamous carcinoma (NCIt: C5721)
Squamous cell carcinoma of pancreas (ORDO: Orphanet_424039)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0221 (COLO 357)
Sex of cell Female
Age at sampling 77Y
Category Cancer cell line
Publications

PubMed=16135802; DOI=10.1128/mcb.25.18.8108-8125.2005; PMCID=PMC1234333
Laurence Levy, Caroline Susan Hill;
Smad4 dependency defines two classes of transforming growth factor beta (TGF-beta) target genes and distinguishes TGF-beta-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses.
Mol. Cell. Biol. 25:8108-8125(2005)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RL60
Encyclopedic resources Wikidata; Q54814100
Entry history
Entry creation05-Mar-2018
Last entry update19-Dec-2024
Version number12