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Cellosaurus CLC5 (CVCL_RH15)

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Cell line name CLC5
Synonyms Chinese Liver Cancer cell line 5
Accession CVCL_RH15
Resource Identification Initiative To cite this cell line use: CLC5 (RRID:CVCL_RH15)
Comments Part of: Liver Cancer Model Repository (LIMORE).
Population: Chinese.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Omics: Genomics; Whole genome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:903; AXIN1; Simple; p.Glu709Ter (c.2125G>T); Zygosity=Unspecified (PubMed=31378681).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31378681).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu68Ter (c.202G>T); ClinVar=VCV000224551; Zygosity=Unspecified (PubMed=27273737; PubMed=31378681).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
STR profile Source(s): PubMed=27273737; PubMed=31378681

Markers:
AmelogeninX
CSF1PO9
D5S81811,12
D7S8209,12
D13S3178
D16S5399,13
TH018
TPOX11,12
vWA14,16

Run an STR similarity search on this cell line
Web pages Provider; BRICS; BRICS0004; http://www.brics.ac.cn/cell/template/cell/cell_detail.html?id=3819
Publications

PubMed=27273737; DOI=10.1038/srep27411; PMCID=PMC4895220
Zhi-Xin Qiu, Ke-Ke Zou, Li-Ping Zhuang, Jian-Jie Qin, Hong Li, Chao Li, Zheng-Tao Zhang, Xiao-Tao Chen, Jin Cen, Zhi-Qiang Meng, Hai-Bin Zhang ...Show all 13 authors... , Yi-Xue Li, Li-Jian Hui; Show fewer authors
Hepatocellular carcinoma cell lines retain the genomic and transcriptomic landscapes of primary human cancers.
Sci. Rep. 6:27411.1-27411.13(2016)

PubMed=31378681; DOI=10.1016/j.ccell.2019.07.001; PMCID=PMC7505724
Zhi-Xin Qiu, Hong Li, Zheng-Tao Zhang, Zhen-Feng Zhu, Sheng He, Xu-Jun Wang, Peng-Cheng Wang, Jian-Jie Qin, Li-Ping Zhuang, Wei Wang, Fu-Bo Xie ...Show all 33 authors... , Ying Gu, Ke-Ke Zou, Chao Li, Chun Li, Chen-Hua Wang, Jin Cen, Xiao-Tao Chen, Ya-Jing Shu, Zhao Zhang, Lu-Lu Sun, Li-Hua Min, Yong Fu, Xiao-Wu Huang, Hui Lv, He Zhou, Yuan Ji, Zhi-Gang Zhang, Zhi-Qiang Meng, Xiao-Lei Shi, Hai-Bin Zhang, Yi-Xue Li, Li-Jian Hui; Show fewer authors
A pharmacogenomic landscape in human liver cancers.
Cancer Cell 36:179-193.e11(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RH15
LIMORE; CLC5
Encyclopedic resources Wikidata; Q54813584
Gene expression databases GEO; GSM2070040
Sequence databases EGA; EGAS00001001678
Entry history
Entry creation05-Mar-2018
Last entry update10-Apr-2025
Version number13