Cellosaurus cell line (CVCL

Cellosaurus (CVCL_RG01)

Comments

Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.

Sequence variations

Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (PubMed=10071127; PubMed=22675565; Cosmic-CLP=909251).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu11Gln (c.31G>C); ClinVar=VCV000041723; Zygosity=Heterozygous (PubMed=10071127; PubMed=22675565; Cosmic-CLP=909251).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Pro (c.743G>C); ClinVar=VCV000237954; Zygosity=Heterozygous (PubMed=10071127; PubMed=22675565; Cosmic-CLP=909251).

Genome ancestry

Source: PubMed=30894373

Origin	% genome
African	0.9
Native American	0.31
East Asian, North	84.31
East Asian, South	13.48
South Asian	0
European, North	0.65
European, South	0.35

Disease

Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

Category

Cancer cell line

STR profile

Source(s): Cosmic-CLP=909251; DSMZ=ACC-34

Markers:

Amelogenin	X
CSF1PO	11,13
D2S1338	17,19
D3S1358	16,17
D5S818	12,13
D7S820	11,12
D8S1179	12,16
D13S317	10,11
D16S539	9,10
D18S51	14,17
D19S433	14
D21S11	30
FGA	21
Penta D	10,13.4
Penta E	10,19
TH01	6,9
TPOX	8,11
vWA	18

Entry history

Entry creation

04-Apr-2012

Last entry update

10-Apr-2025

Version number