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ER stress and autophagic perturbations lead to elevated extracellular alpha-synuclein in GBA-N370S Parkinson's iPSC-derived dopamine neurons.
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Haenseler W., Sansom S.N., Buchrieser J., Newey S.E., Moore C.S., Nicholls F.J., Chintawar S., Schnell C., Antel J.P., Allen N.D., Cader M.Z., Wade-Martins R., James W.S., Cowley S.A.
A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response.
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Excess alpha-synuclein compromises phagocytosis in iPSC-derived macrophages.
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PubMed=32359446; DOI=10.1016/j.stemcr.2020.04.001
Lee H., Flynn R., Sharma I., Haberman E., Carling P.J., Nicholls F.J., Stegmann M., Vowles J., Haenseler W., Wade-Martins R., James W.S., Cowley S.A.
LRRK2 is recruited to phagosomes and co-recruits RAB8 and RAB10 in human pluripotent stem cell-derived macrophages.
Stem Cell Reports 14:940-955(2020)