Cellosaurus cell line STBCi025-B (CVCL

Cellosaurus STBCi025-B (CVCL_RB83)

Cross-references
Cell line name	STBCi025-B
Synonyms	SFC834-03-03
Accession	CVCL_RB83
Resource Identification Initiative	To cite this cell line use: STBCi025-B (RRID:CVCL_RB83)
Comments	From: StemBANCC; Oxford; United Kingdom. Cell type: Fibroblast; CL=CL_0000057.
Sequence variations	Mutation; HGNC; HGNC:4177; GBA1; Simple; p.Asn409Ser (c.1226A>G) (N370S); ClinVar=VCV000004290; Zygosity=Heterozygous (PubMed=26905200).
Disease	Parkinson disease (NCIt: C26845) Hereditary late-onset Parkinson disease (ORDO: Orphanet_411602)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual	CVCL_RB82 ! STBCi025-A CVCL_RB84 ! STBCi025-C
Sex of cell	Male
Age at sampling	72Y
Category	Induced pluripotent stem cell
Publications	PubMed=26905200; DOI=10.1016/j.stemcr.2016.01.013; PMCID=PMC4788783 Hugo J.R. Fernandes, Elizabeth M. Hartfield, Helen C. Christian, Evangelia Emmanoulidou, Ying Zheng, Heather Booth, Helle Bogetofte, Charmaine Lang, Brent J. Ryan, S. Pablo Sardi, Jennifer Badger ...Show all 20 authors... , Jane Vowles, Samuel Evetts, George K. Tofaris, Kostas Vekrellis, Kevin Talbot, Michele T. Hu, William S. James, Sally Anne Cowley, Richard Wade-Martins; Show fewer authors ER stress and autophagic perturbations lead to elevated extracellular alpha-synuclein in GBA-N370S Parkinson's iPSC-derived dopamine neurons. Stem Cell Reports 6:342-356(2016) PubMed=30503143; DOI=10.1016/j.stem.2018.10.023; PMCID=PMC6327112 Charmaine Lang, Kieran R. Campbell, Brent J. Ryan, Phillippa J. Carling, Moustafa Attar, Jane Vowles, Olga V. Perestenko, Rory Bowden, Fahd Baig, Meike Kasten, Michele T. Hu ...Show all 14 authors... , Sally Anne Cowley, Caleb Webber, Richard Wade-Martins; Show fewer authors Single-cell sequencing of iPSC-dopamine neurons reconstructs disease progression and identifies HDAC4 as a regulator of Parkinson cell phenotypes. Cell Stem Cell 24:93-106.e6(2019)
Cell line collections (Providers)	EBiSC; STBCi025-B ECACC; 66540692 - Discontinued
Cell line databases/resources	hPSCreg; STBCi025-B
Biological sample resources	BioSamples; SAMEA104493658
Encyclopedic resources	Wikidata; Q54956406
Entry history
Entry creation	05-Mar-2018
Last entry update	10-Apr-2025
Version number	15