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Cellosaurus MCF-7 shPARG (CVCL_RA89)

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Cell line name MCF-7 shPARG
Synonyms shPARG MCF7
Accession CVCL_RA89
Resource Identification Initiative To cite this cell line use: MCF-7 shPARG (RRID:CVCL_RA89)
Comments Population: Caucasian.
Knockout cell: Method=shRNA knockdown; HGNC; HGNC:8605; PARG.
Omics: Proteomics; PTM; Poly-ADP-ribosylation.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=29166620; DOI=10.1016/j.celrep.2017.10.106; PMCID=PMC5728415
Yuan-Li Zhen, Ya-Jie Zhang, Yong-Hao Yu;
A cell-line-specific atlas of PARP-mediated protein Asp/Glu-ADP-ribosylation in breast cancer.
Cell Rep. 21:2326-2337(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RA89
Encyclopedic resources Wikidata; Q54904325
Entry history
Entry creation05-Mar-2018
Last entry update10-Apr-2025
Version number12