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Cellosaurus LNCaP-EnzR (CVCL_RA57)

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Cell line name LNCaP-EnzR
Accession CVCL_RA57
Resource Identification Initiative To cite this cell line use: LNCaP-EnzR (RRID:CVCL_RA57)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_68534; Enzalutamide (Xtandi; MDV-3100).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0395 (LNCaP)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Publications

PubMed=27036029; DOI=10.18632/oncotarget.8456; PMCID=PMC5041979
Steven Kregel, James L. Chen, Westin Tom, Venkatesh Krishnan, Jacob Kach, Hannah Brechka, Tim B. Fessenden, Masis Isikbay, Gladell Pador Paner, Russell Z. Szmulewitz, Donald J. Vander Griend;
Acquired resistance to the second-generation androgen receptor antagonist enzalutamide in castration-resistant prostate cancer.
Oncotarget 7:26259-26274(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RA57
Encyclopedic resources Wikidata; Q54902837
Gene expression databases GEO; GSM2069526
GEO; GSM2069527
GEO; GSM2069528
GEO; GSM2069529
Entry history
Entry creation05-Mar-2018
Last entry update10-Apr-2025
Version number12