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Cellosaurus CWR-R1-EnzR (CVCL_RA55)

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Cell line name CWR-R1-EnzR
Accession CVCL_RA55
Resource Identification Initiative To cite this cell line use: CWR-R1-EnzR (RRID:CVCL_RA55)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_68534; Enzalutamide (Xtandi; MDV-3100).
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Prostate; UBERON=UBERON_0002367.
Sequence variations
  • Mutation; HGNC; HGNC:644; AR; Simple; p.His875Tyr (c.2623C>T); ClinVar=VCV000009834; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln331Arg (c.992A>G); ClinVar=VCV000421319; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4833 (CWR-R1)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=27036029; DOI=10.18632/oncotarget.8456; PMCID=PMC5041979
Steven Kregel, James L. Chen, Westin Tom, Venkatesh Krishnan, Jacob Kach, Hannah Brechka, Tim B. Fessenden, Masis Isikbay, Gladell Pador Paner, Russell Z. Szmulewitz, Donald J. Vander Griend;
Acquired resistance to the second-generation androgen receptor antagonist enzalutamide in castration-resistant prostate cancer.
Oncotarget 7:26259-26274(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RA55
Encyclopedic resources Wikidata; Q54817050
Gene expression databases GEO; GSM2069494
GEO; GSM2069495
GEO; GSM2069496
GEO; GSM2069497
Entry history
Entry creation05-Mar-2018
Last entry update10-Apr-2025
Version number12