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Cellosaurus MCS-2 [Human breast carcinoma] (CVCL_R955)

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Cell line name MCS-2 [Human breast carcinoma]
Accession CVCL_R955
Resource Identification Initiative To cite this cell line use: MCS-2 [Human breast carcinoma] (RRID:CVCL_R955)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:11425; STS.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=14623544; DOI=10.1016/S0960-0760(03)00357-1
Taisuke Nakata, Shigemitsu Takashima, Yukimasa Shiotsu, Chikara Murakata, Hiroyuki Ishida, Shiro Akinaga, Pui-Ki Li, Hironobu Sasano, Takashi Suzuki, Toshiaki Saeki;
Role of steroid sulfatase in local formation of estrogen in post-menopausal breast cancer patients.
J. Steroid Biochem. Mol. Biol. 86:455-460(2003)

Cross-references
Cell line databases/resources cancercelllines; CVCL_R955
Anatomy/cell type resources BTO; BTO_0002271
Encyclopedic resources Wikidata; Q54904534
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number19