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Cellosaurus CHO/IR (CVCL_R864)

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Cell line name CHO/IR
Synonyms CHO-IR
Accession CVCL_R864
Resource Identification Initiative To cite this cell line use: CHO/IR (RRID:CVCL_R864)
Comments Genetic integration: Method=Transfection; Gene=HGNC; HGNC:6091; INSR.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_0213 (CHO)
Children:
CVCL_R865 (CHO/IR/IRS-1)CVCL_R867 (CHO/IR/IRS-2)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=1385403; DOI=10.1016/S0021-9258(18)41723-1
Xiao-Jian Sun, Montserrat Miralpeix, Martin G. Myers Jr., Erin M. Glasheen, Jonathan M. Backer, Carl Ronald Kahn, Morris Francis White;
Expression and function of IRS-1 in insulin signal transmission.
J. Biol. Chem. 267:22662-22672(1992)

PubMed=10389839; DOI=10.2337/diabetes.48.7.1359
Xiao-Jian Sun, Jonathan L. Goldberg, Li-Ya Qiao, John J. Mitchell;
Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.
Diabetes 48:1359-1364(1999)

Cross-references
Encyclopedic resources Wikidata; Q54813157
Experimental variables resources EFO; EFO_0022827
Entry history
Entry creation05-Nov-2013
Last entry update14-Aug-2025
Version number14