Cellosaurus logo
expasy logo

Cellosaurus SNU-2535 (CVCL_R756)

[Text][XML][JSON]
Cell line name SNU-2535
Accession CVCL_R756
Resource Identification Initiative To cite this cell line use: SNU-2535 (RRID:CVCL_R756)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: Seoul National University (SNU) cell line collection.
Population: Korean.
Characteristics: Resistant to crizotinib (PubMed=23344087).
Doubling time: 61 hours (CelloPub=CLPUB00546).
Omics: Genomics; Whole exome sequencing.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene fusion; HGNC; HGNC:427; ALK + HGNC; HGNC:1316; EML4; Name(s)=EML4-ALK (CelloPub=CLPUB00546; PubMed=35852680).
  • Mutation; HGNC; HGNC:427; ALK; Simple; p.Gly1269Ala (c.3806G>C); ClinVar=VCV000376132; Zygosity=Heterozygous (CelloPub=CLPUB00546; PubMed=35852680; DepMap=ACH-002531).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C5TR (SNU-2535LR)
Sex of cell Female
Age at sampling 57Y
Category Cancer cell line
STR profile Source(s): KCLB=02535; CelloPub=CLPUB00546

Markers:
AmelogeninX
CSF1PO11
D2S133820,23
D3S135814,15 (CelloPub=CLPUB00546)
15 (KCLB=02535)
D5S81810,12
D7S82011
D8S117913,15
D13S3179,11
D16S5399,11
D18S5115
D19S43310.2,14
D21S1128,29
FGA24,27
TH017,9.3
TPOX11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=23344087; DOI=10.1097/JTO.0b013e318283dcc0
Soyeon Kim, Tae Min Kim, Dong-Wan Kim, Heounjeong Go, Bhumsuk Keam, Se-Hoon Lee, Ja-Lok Ku, Doo Hyun Chung, Dae Seog Heo;
Heterogeneity of genetic changes associated with acquired crizotinib resistance in ALK-rearranged lung cancer.
J. Thorac. Oncol. 8:415-422(2013)

CLPUB00546
Ha-Young Seo;
Establishment and characterization of 28 human lung cancer cell lines derived from pleural effusions.
Thesis MSc (2019); Seoul National University College of Medicine; Seoul; South Korea

PubMed=35852680; DOI=10.1007/s12094-022-02884-x
Bo Xie, Ying Qiu, Juan Zhou, Dou Du, Hao-Chuan Ma, Jia-Peng Ji, Li-Quan Zhu, Wei-Min Zhang;
Establishment of an acquired lorlatinib-resistant cell line of non-small cell lung cancer and its mediated resistance mechanism.
Clin. Transl. Oncol. 24:2231-2240(2022)

Cross-references
Cell line collections (Providers) KCLB; 02535
Cell line databases/resources cancercelllines; CVCL_R756
DepMap; ACH-002531
Encyclopedic resources Wikidata; Q54955156
Polymorphism and mutation databases Cosmic; 1859888
Entry history
Entry creation05-Nov-2013
Last entry update10-Apr-2025
Version number19