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Cellosaurus A375-16R6-2 (CVCL_R753)

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Cell line name A375-16R6-2
Synonyms 16R6-2
Accession CVCL_R753
Resource Identification Initiative To cite this cell line use: A375-16R6-2 (RRID:CVCL_R753)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_75045; Dabrafenib (Tafinlar; GSK2118436).
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_R745 (A375PF11)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Publications

PubMed=22389471; DOI=10.1158/1535-7163.MCT-11-0989
James G. Greger, Stephen D. Eastman, Vivian Zhang, Maureen R. Bleam, Ashley M. Hughes, Kimberly N. Smitheman, Scott H. Dickerson, Sylvie G. Laquerre, Li Liu, Tona Morgan Gilmer;
Combinations of BRAF, MEK, and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib, mediated by NRAS or MEK mutations.
Mol. Cancer Ther. 11:909-920(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_R753
Encyclopedic resources Wikidata; Q54606767
Polymorphism and mutation databases Cosmic; 1890492
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number18