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Cellosaurus ANBL-6 BR (CVCL_QZ43)

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Cell line name ANBL-6 BR
Accession CVCL_QZ43
Resource Identification Initiative To cite this cell line use: ANBL-6 BR (RRID:CVCL_QZ43)
Comments Population: Caucasian.
Characteristics: Produces Ig lambda.
Characteristics: IL6 dependent.
Selected for resistance to: ChEBI; CHEBI_52717; Bortezomib (Velcade).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Plasma cell; CL=CL_0000786.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln331Ter (c.991C>T); ClinVar=VCV000922893; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:12033; TRAF3; Simple; p.Tyr425Thrfs*36 (c.1272delC); Zygosity=Homozygous (from parent cell line).
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5425 (ANBL-6)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
Publications

PubMed=19344406; DOI=10.1111/j.1365-2141.2009.07647.x; PMCID=PMC3018832
Peter M. Voorhees, Qing Chen, George W. Small, Deborah J. Kuhn, Sally A. Hunsucker, Jeffrey A. Nemeth, Robert Z. Orlowski;
Targeted inhibition of interleukin-6 with CNTO 328 sensitizes pre-clinical models of multiple myeloma to dexamethasone-mediated cell death.
Br. J. Haematol. 145:481-490(2009)

Cross-references
Cell line databases/resources cancercelllines; CVCL_QZ43
Encyclopedic resources Wikidata; Q54749909
Entry history
Entry creation05-Mar-2018
Last entry update14-Aug-2025
Version number11