Cellosaurus cell line MDA-T85 (CVCL

Cellosaurus MDA-T85 (CVCL_QW84)

[Text version]

Cell line name

MDA-T85

Accession

CVCL_QW84

Resource Identification Initiative

To cite this cell line use: MDA-T85 (RRID:CVCL_QW84)

Comments

Population: Hispanic.
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.

Sequence variations

Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=25427145; PubMed=30737244).
Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000012601; Zygosity=Heterozygous (PubMed=25427145; PubMed=30737244).
Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=25427145; PubMed=30737244).

Disease

Thyroid gland papillary carcinoma (NCIt: C4035)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

61Y

Category

Cancer cell line

STR profile

Source(s): ATCC=CRL-3354; PubMed=25427145; PubMed=30737244

Markers:

Amelogenin	X,Y
CSF1PO	9,10
D5S818	9,12
D7S820	11
D13S317	9,10
D16S539	10
TH01	6,9.3
TPOX	8
vWA	17

Publications

PubMed=25427145; DOI=10.1210/jc.2014-2624; PMCID=PMC4318904
Ying C. Henderson, Soon-Hyun Ahn, Junsun Ryu, Yun-Yun Chen, Michelle D. Williams, Adel K. El-Naggar, Mihai Gagea, Rebecca E. Schweppe, Bryan R. Haugen, Stephen Y. Lai, Gary L. Clayman;
Development and characterization of six new human papillary thyroid carcinoma cell lines.
J. Clin. Endocrinol. Metab. 100:E243-E252(2015)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Inigo Landa, Nikita Pozdeyev, Christopher T. Korch, Laura A. Marlow, Robert Christian Smallridge, John Alton Copland 3rd, Ying C. Henderson, Stephen Y. Lai, Gary L. Clayman, Naoyoshi Onoda, Aik-Choon Tan ...Show all 16 authors... , Maria E.R. Garcia-Rendueles, Jeffrey A. Knauf, Bryan R. Haugen, James Alexander Fagin, Rebecca E. Schweppe; Show fewer authors
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references

Cell line collections (Providers)

ATCC; CRL-3354

Cell line databases/resources

cancercelllines; CVCL_QW84

Encyclopedic resources

Wikidata; Q54904663

Polymorphism and mutation databases

Cosmic; 2612754

Entry history

Entry creation

15-Nov-2017

Last entry update

10-Apr-2025

Version number