Cellosaurus logo
expasy logo

Cellosaurus TC-CD99-shRNA#1 (CVCL_QW72)

[Text][XML][JSON]
Cell line name TC-CD99-shRNA#1
Accession CVCL_QW72
Resource Identification Initiative To cite this cell line use: TC-CD99-shRNA#1 (RRID:CVCL_QW72)
Comments Population: Caucasian.
Knockout cell: Method=shRNA knockdown; HGNC; HGNC:7082; CD99.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Bone, humerus; UBERON=UBERON_0000976.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1 (from parent cell line).
  • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Unspecified (from parent cell line).
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2213 (TC-71)
Sex of cell Male
Age at sampling 22Y
Category Cancer cell line
Publications

PubMed=20197622; DOI=10.1172/JCI36667; PMCID=PMC2827943
Anna Rocchi, Maria Cristina Manara, Marika Sciandra, Diana Zambelli, Filippo Nardi, Giordano Nicoletti, Cecilia Garofalo, Stefania Meschini, Annalisa Astolfi, Mario P. Colombo, Stephen Lee Lessnick ...Show all 13 authors... , Piero Picci, Katia Scotlandi; Show fewer authors
CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis.
J. Clin. Invest. 120:668-680(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_QW72
Encyclopedic resources Wikidata; Q54971825
Gene expression databases GEO; GSM278143
GEO; GSM278144
Entry history
Entry creation15-Nov-2017
Last entry update10-Apr-2025
Version number13