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Cellosaurus TC-CTR-shRNA (CVCL_QW71)

[Text version]
Cell line name TC-CTR-shRNA
Accession CVCL_QW71
Resource Identification Initiative To cite this cell line use: TC-CTR-shRNA (RRID:CVCL_QW71)
Comments Population: Caucasian.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Bone, humerus; UBERON=UBERON_0000976.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Gene fusion; HGNC; 3508; EWSR1 + HGNC; 3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1 (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Unspecified (from parent cell line).
Disease Ewing sarcoma (NCIt: C4817)
Ewing sarcoma (ORDO: Orphanet_319)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2213 (TC-71)
Sex of cell Male
Age at sampling 22Y
Category Cancer cell line
Publications

PubMed=20197622; DOI=10.1172/JCI36667
Rocchi A., Manara M.C., Sciandra M., Zambelli D., Nardi F., Nicoletti G., Garofalo C., Meschini S., Astolfi A., Colombo M.P., Lessnick S.L., Picci P., Scotlandi K.
CD99 inhibits neural differentiation of human Ewing sarcoma cells and thereby contributes to oncogenesis.
J. Clin. Invest. 120:668-680(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_QW71
Encyclopedic resources Wikidata; Q54971827
Gene expression databases GEO; GSM278141
GEO; GSM278142
Entry history
Entry creation15-Nov-2017
Last entry update05-Oct-2023
Version number11