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Cellosaurus Ma-Mel-48b (CVCL_N786)

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Cell line name Ma-Mel-48b
Accession CVCL_N786
Resource Identification Initiative To cite this cell line use: Ma-Mel-48b (RRID:CVCL_N786)
Comments Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Gene deletion; HGNC; HGNC:914; B2M; Zygosity=Heterozygous (PubMed=25294904).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Gly469Arg (c.1405G>A); ClinVar=VCV000177775; Zygosity=Unspecified (PubMed=23348503).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (PubMed=23348503).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_A183 ! Ma-Mel-48a
CVCL_N787 ! Ma-Mel-48c
Sex of cell Male
Age at sampling 88Y
Category Cancer cell line
Publications

PubMed=23348503; DOI=10.1126/science.1230062
Susanne Horn, Adina Figl, P. Sivaramakrishna Rachakonda, Christine Fischer, Antje Sucker, Andreas Gast, Stephanie Kadel, Iris Moll, Eduardo Nagore, Kari Hemminki, Dirk Schadendorf, Rajiv Kumar;
TERT promoter mutations in familial and sporadic melanoma.
Science 339:959-961(2013)

PubMed=25294904; DOI=10.1158/1078-0432.CCR-14-0567; PMCID=PMC8728890
Antje Sucker, Fang Zhao, Birgit Real, Christina Heeke, Nicola Bielefeld, Stefan Massen, Susanne Horn, Iris Moll, Raffaela Maltaner, Peter A. Horn, Bastian Schilling ...Show all 19 authors... , Francesco Sabbatino, Volker Lennerz, Matthias Kloor, Soldano Ferrone, Dirk Schadendorf, Christine S. Falk, Klaus Georg Griewank, Annette Paschen; Show fewer authors
Genetic evolution of T-cell resistance in the course of melanoma progression.
Clin. Cancer Res. 20:6593-6604(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_N786
Encyclopedic resources Wikidata; Q54903806
Gene expression databases GEO; GSM1467847
Polymorphism and mutation databases Cosmic; 1846630
Cosmic; 2686418
Cosmic; 2757114
Progenetix; CVCL_N786
Entry history
Entry creation05-Nov-2013
Last entry update10-Apr-2025
Version number13