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Cellosaurus MA-1 [Human contaminated lymphoma] (CVCL_M665)

[Text version]
Cell line name MA-1 [Human contaminated lymphoma]
Synonyms Ma-1
Accession CVCL_M665
Resource Identification Initiative To cite this cell line use: MA-1 [Human contaminated lymphoma] (RRID:CVCL_M665)
Comments Problematic cell line: Contaminated. Shown to be a Pfeiffer derivative (PubMed=23907998) and not a mucosa-associated lymphoid tissue (MALT) lymphoma cell line. This finding is disputed by the original authors (PubMed=24285409).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00471.
Population: Caucasian.
Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Arg1171Cys (c.3511C>T); ClinVar=VCV000133518; Zygosity=Heterozygous (from parent cell line).
Disease Diffuse large B-cell lymphoma germinal center B-cell type (NCIt: C36080)
Diffuse large B-cell lymphoma (ORDO: Orphanet_544)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3326 (Pfeiffer)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx

PubMed=21837708; DOI=10.1002/gcc.20910
Kuo S.-H., Weng W.-H., Chen Z.-H., Hsu P.-N., Wu M.-S., Lin C.-W., Jeng H.-J., Yeh K.-H., Tsai H.-J., Chen L.-T., Cheng A.-L.
Establishment of a novel MALT lymphoma cell line, Ma-1, from a patient with t(14;18)(q32;q21)-positive Helicobacter pylori-independent gastric MALT lymphoma.
Genes Chromosomes Cancer 50:908-921(2011)

PubMed=23508748; DOI=10.1002/gcc.22051
Kuo S.-H., Yeh K.-H., Cheng A.-L., Weng W.-H., Chen L.-T.
No evidence of IGH-MALT1-translocation in the Ma-1 cell line -- a reply.
Genes Chromosomes Cancer 52:593-594(2013)

PubMed=23508779; DOI=10.1002/gcc.22052
Flossbach L., Barth T.F.E., Moller P.
No evidence of IGH-MALT1 translocation in the Ma-1 cell line.
Genes Chromosomes Cancer 52:591-592(2013)

PubMed=23907998; DOI=10.1002/gcc.22094
Capes-Davis A., Alston-Roberts C., Kerrigan L., Reid Y.A., Barrett T., Burnett E.C., Cooper J.R., Freshney R.I., Healy L.E., Kohara A., Korch C.T., Masters J.R.W., Nakamura Y., Nims R.W., Storts D.R., Dirks W.G., MacLeod R.A.F., Drexler H.G.
Beware imposters: MA-1, a novel MALT lymphoma cell line, is misidentified and corresponds to Pfeiffer, a diffuse large B-cell lymphoma cell line.
Genes Chromosomes Cancer 52:986-988(2013)

PubMed=24285409; DOI=10.1002/gcc.22122
Kuo S.-H., Tsai H.-J., Weng W.-H., Li C.-C., Yeh K.-H., Chen L.-T., Cheng A.-L.
Comments on: 'beware imposters: MA-1, a novel MALT lymphoma cell line, is misidentified and corresponds to Pfeiffer, a diffuse large B-cell lymphoma cell line-A'. Reply: despite the same 8-code STR, MA-1 and Pfeiffer are cytogenetically diverse.
Genes Chromosomes Cancer 53:211-213(2014)

Cell line databases/resources cancercelllines; CVCL_M665
Biological sample resources BioSample; SAMN03151897
Encyclopedic resources Wikidata; Q54903677
Entry history
Entry creation05-Nov-2013
Last entry update02-May-2024
Version number20