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Cellosaurus Seraphina (CVCL_M646)

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Cell line name Seraphina
Synonyms SERAPHINA; Seraphine; SERAP; U-604 BL
Accession CVCL_M646
Resource Identification Initiative To cite this cell line use: Seraphina (RRID:CVCL_M646)
Comments Population: African; Kenyan.
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Variations; Array-based CGH.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: B-cell; CL=CL_0000236.
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 7Y
Category Cancer cell line
STR profile Source(s): PubMed=17254797

Markers:
AmelogeninX
CSF1PO11
D3S135817
D5S81812
D7S8208,10
D8S117912,14
D13S31712
D16S53910
D18S5116,17
D21S1127
FGA23,25
TH016,9
TPOX10,11
vWA15,16

Run an STR similarity search on this cell line
Publications

PubMed=4122458; DOI=10.1002/ijc.2910100108
George Klein, Laszlo Dombos, Balwant Gothoskar;
Sensitivity of Epstein-Barr virus (EBV) producer and non-producer human lymphoblastoid cell lines to superinfection with EB-virus.
Int. J. Cancer 10:44-57(1972)

PubMed=4364259; DOI=10.1002/ijc.2910110210
George Klein, Laszlo Dombos;
Relationship between the sensitivity of EBV-carrying lymphoblastoid lines to superinfection and the inducibility of the resident viral genome.
Int. J. Cancer 11:327-337(1973)

PubMed=163717; DOI=10.1016/0090-1229(75)90082-3
Eva Klein, Kenneth Nilsson, Eitan Yefenof;
An established Burkitt's lymphoma line with cell membrane IgG.
Clin. Immunol. Immunopathol. 3:575-583(1975)

PubMed=165156; DOI=10.1002/ijc.2910150217
Kenneth Nilsson, Jan Ponten;
Classification and biological nature of established human hematopoietic cell lines.
Int. J. Cancer 15:321-341(1975)

PubMed=216485
Norman Patrick Higgins, Bernard S. Strauss;
Differences in the ability of human lymphoblastoid lines to exclude bromodeoxyuridine and in their sensitivity to methyl methanesulfonate and to incorporated [3H]thymidine.
Cancer Res. 39:312-320(1979)

PubMed=6286514; DOI=10.1002/ijc.2910290609
Joelle Wiels, Gilbert Marcel Lenoir, Marc Fellous, Marc Lipinski, Jean-Claude Salomon, Cecile Tetaud, Thomas Tursz;
A monoclonal antibody with anti-Burkitt lymphoma specificity. I Analysis of human haematopoietic and lymphoid cell lines.
Int. J. Cancer 29:653-658(1982)

PubMed=6231253; DOI=10.1002/ijc.2910330407
Barbro Ehlin-Henriksson, George Klein;
Distinction between Burkitt lymphoma subgroups by monoclonal antibodies: relationships between antigen expression and type of chromosomal translocation.
Int. J. Cancer 33:459-463(1984)

PubMed=3026973; DOI=10.1002/ijc.2910390215
Barbro Ehlin-Henriksson, Agneta Manneborg-Sandlund, George Klein;
Expression of B-cell-specific markers in different Burkitt lymphoma subgroups.
Int. J. Cancer 39:211-218(1987)

PubMed=3027441; DOI=10.1093/jnci/78.2.235
Jacques H.M. Cohen, Jean-Pierre Revillard, Jean-Pierre Magaud, Gilbert Marcel Lenoir, Michele Vuillaume, Anne-Marie Manel, Claude Vincent, Paul-Andre Bryon;
B-cell maturation stages of Burkitt's lymphoma cell lines according to Epstein-Barr virus status and type of chromosome translocation.
J. Natl. Cancer Inst. 78:235-242(1987)

PubMed=9473234; DOI=10.1182/blood.V91.5.1680
Ulf Klangby, Ismail Okan, Kristinn Petur Magnusson, Martin Wendland, Peter Lind, Klas G. Wiman;
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Blood 91:1680-1687(1998)

PubMed=16960149; DOI=10.1182/blood-2006-06-026500
Cinta Mestre-Escorihuela, Fanny Rubio-Moscardo, Jose A. Richter, Reiner Siebert, Joan Climent, Vicente Fresquet, Elena Beltran, Xabier Agirre, Isabel Marugan, Miguel Marin, Andreas Rosenwald ...Show all 21 authors... , Kei-ji Sugimoto, Luise M. Wheat, E. Loraine Karran, Juan Fernando Garcia Garcia, Lydia Sanchez-Verde, Felipe Prosper, Louis Michael Staudt, Daniel Pinkel, Martin John Swinnerton Dyer, Jose Angel Martinez-Climent; Show fewer authors
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Blood 109:271-280(2007)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Shahram Azari, Nahid Ahmadi, Mahmood Jeddi-Tehrani, Fazel Shokri;
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=24590883; DOI=10.1002/gcc.22161
Eva-Maria Murga Penas, Georgia Schilling, Petra Behrmann, Marianne Klokow, Eik Vettorazzi, Carsten Bokemeyer, Judith Dierlamm;
Comprehensive cytogenetic and molecular cytogenetic analysis of 44 Burkitt lymphoma cell lines: secondary chromosomal changes characterization, karyotypic evolution, and comparison with primary samples.
Genes Chromosomes Cancer 53:497-515(2014)

Cross-references
Cell line collections (Providers) NCBI_Iran; C102
Cell line databases/resources cancercelllines; CVCL_M646
Encyclopedic resources Wikidata; Q54952813
Gene expression databases GEO; GSM115813
Polymorphism and mutation databases Cosmic; 931112
Cosmic; 2297025
Progenetix; CVCL_M646
Entry history
Entry creation05-Nov-2013
Last entry update14-Aug-2025
Version number19