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Cellosaurus 105KC (CVCL_M605)

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Cell line name 105KC
Synonyms 105 KC; KC
Accession CVCL_M605
Resource Identification Initiative To cite this cell line use: 105KC (RRID:CVCL_M605)
Comments Doubling time: 36 hours (PubMed=16039953).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Miscellaneous: STR profile established at MicroSynth from personal communication of Muff, Roman.
Derived from site: In situ; Bone, distal femur; UBERON=UBERON_0004406.
Disease Chondrosarcoma (NCIt: C2946)
Chondrosarcoma (ORDO: Orphanet_55880)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_M609 (105AJ)CVCL_M608 (KC2H3)
Sex of cell Male
Age at sampling 66Y
Category Cancer cell line
STR profile Source(s): Microsynth; PubMed=25877200

Markers:
AmelogeninX
CSF1PO10,11
D3S135815,17
D5S81810,11
D7S82010,13
D8S117913,16
D13S3178 (Microsynth)
8,11 (PubMed=25877200)
D16S5399,12,14 (PubMed=25877200)
9,14 (Microsynth)
D18S5115,16 (Microsynth)
15,19 (PubMed=25877200)
D21S1131.2,32.2
FGA21,23 (PubMed=25877200)
23 (Microsynth)
Penta D13
Penta E5,20
TH019
TPOX8
vWA15,18

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Publications

PubMed=2045389
Joel A. Block, Sven E. Inerot, Steven Gitelis, James H. Kimura;
Synthesis of chondrocytic keratan sulphate-containing proteoglycans by human chondrosarcoma cells in long-term cell culture.
J. Bone Joint Surg. Am. 73:647-658(1991)

PubMed=10906887; DOI=10.1097/00003086-200007000-00038
Sean P. Scully, Keith R. Berend, Alison Toth, Wen-Ning Qi, Zhou Qi, Joel A. Block;
Interstitial collagenase gene expression correlates with in vitro invasion in human chondrosarcoma.
Clin. Orthop. Relat. Res. 376:291-303(2000)

PubMed=12354749
James A. Martin, Erin Forest, Joel A. Block, Aloysius J. Klingelhutz, Brent Whited, Steven Gitelis, Andrew Wilkey, Joseph A. Buckwalter;
Malignant transformation in human chondrosarcoma cells supported by telomerase activation and tumor suppressor inactivation.
Cell Growth Differ. 13:397-407(2002)

PubMed=16039953; DOI=10.1016/j.canlet.2004.11.022
Cornelius M. Schorle, Florian Finger, Alexander Zien, Joel A. Block, Pia Margarethe Gebhard, Thomas Aigner;
Phenotypic characterization of chondrosarcoma-derived cell lines.
Cancer Lett. 226:143-154(2005)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

Cross-references
Biological sample resources BioSample; SAMN03470879
Chemistry resources PharmacoDB; 105KC_1_2019
Encyclopedic resources Wikidata; Q54399871
Experimental variables resources EFO; EFO_0006354
Gene expression databases ArrayExpress; E-MTAB-2706
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation05-Nov-2013
Last entry update10-Apr-2025
Version number21