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Cellosaurus CRMM-1 (CVCL_M593)

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Cell line name CRMM-1
Synonyms CRMM1; Conjunctival Recurrent Malignant Melanoma-1
Accession CVCL_M593
Resource Identification Initiative To cite this cell line use: CRMM-1 (RRID:CVCL_M593)
Comments Characteristics: Can form 3D spheroids (PubMed=32545782).
Doubling time: ~60 hours (Note=At 20-40th passages) (PubMed=15993408).
Derived from site: In situ; Eye, bulbar conjunctiva; UBERON=UBERON_0010306.
Sequence variations
Disease Conjunctival melanoma (NCIt: C4550)
Conjunctival malignant melanoma (ORDO: Orphanet_617910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=25722211

Markers:
AmelogeninX
CSF1PO10,13
D2S133817,20
D3S135815,18
D5S81812,13
D7S8208,11
D8S117914
D13S31712
D16S53911
D18S5112,17
D19S43313,14
D21S1129,32.2
FGA21,23
TH017
TPOX8,11
vWA15

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Publications

PubMed=15993408; DOI=10.1016/j.exer.2005.04.018
Gordon Nareyeck, Henrike Wuestemeyer, Daniela von der Haar, Gerasimos Anastassiou;
Establishment of two cell lines derived from conjunctival melanomas.
Exp. Eye Res. 81:361-362(2005)

PubMed=22275346; DOI=10.1136/bjophthalmol-2011-300686
Henrike Westekemper, Michael Freistuehler, Gerasimos Anastassiou, Gordon Nareyeck, Norbert Bornfeld, Klaus-Peter Steuhl, Max E. Scheulen, Ralf Axel Hilger;
Chemosensitivity of conjunctival melanoma cell lines to single chemotherapeutic agents and combinations.
Br. J. Ophthalmol. 96:591-596(2012)

PubMed=25722211; DOI=10.1167/iovs.14-15239
Nadine E. de Waard, Jin-Feng Cao, Sean P. McGuire, Paraskevi Evi Kolovou, Ekaterina S. Jordanova, Bruce R. Ksander, Martine Johanna Jager;
A murine model for metastatic conjunctival melanoma.
Invest. Ophthalmol. Vis. Sci. 56:2325-2333(2015)

PubMed=28903377; DOI=10.18632/oncotarget.18039; PMCID=PMC5589616
Jin-Feng Cao, Niels J. Brouwer, Kate E. Richards, Marina Marinkovic, Sjoerd van Duinen, Daan P. Hurkmans, Elizabeth M.E. Verdegaal, Ekaterina S. Jordanova, Martine Johanna Jager;
PD-L1/PD-1 expression and tumor-infiltrating lymphocytes in conjunctival melanoma.
Oncotarget 8:54722-54734(2017)

PubMed=32545782; DOI=10.3390/biomedicines8060158; PMCID=PMC7344416
Miltiadis Fiorentzis, Periklis Katopodis, Helen Kalirai, Berthold Seitz, Arne Viestenz, Sarah E. Coupland;
Image analysis of 3D conjunctival melanoma cell cultures following electrochemotherapy.
Biomedicines 8:158.1-158.13(2020)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M593
Encyclopedic resources Wikidata; Q54814503
Polymorphism and mutation databases Cosmic; 2639616
Entry history
Entry creation05-Nov-2013
Last entry update10-Apr-2025
Version number15