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Cellosaurus FR4 (CVCL_M505)

[Text version]
Cell line name FR4
Synonyms FR-4
Accession CVCL_M505
Resource Identification Initiative To cite this cell line use: FR4 (RRID:CVCL_M505)
Comments Population: Japanese.
Characteristics: Produces IgA kappa.
Doubling time: 131 hours (PubMed=1697013).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
Cell type: Plasma cell; CL=CL_0000786.
Disease Plasma cell myeloma (NCIt: C3242)
Multiple myeloma (ORDO: Orphanet_29073)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_M504 ! AD3 [Human myeloma]
Sex of cell Male
Age at sampling 69Y
Category Cancer cell line
Web pages Info; Keats Lab; -; https://www.keatslab.org/myeloma-cell-lines
Publications

PubMed=1697013
Shinichi Tagawa, Shoichi Doi, Masafumi Taniwaki, Tatsuo Abe, Yoshio Kanayama, Junzo Nojima, Ken-ichi Matsubara, Teruo Kitani;
Amylase-producing plasmacytoma cell lines, AD3 and FR4, with der(14)t(8;14) and dic(8)t(1;8) established from ascites.
Leukemia 4:600-605(1990)

PubMed=10557056; DOI=10.1038/sj.leu.2401563
S. Yoshida, Naozo Nakazawa, S. Iida, Yoshihito Hayami, S. Sato, Atsushi Wakita, S. Shimizu, Masafumi Taniwaki, R. Ueda;
Detection of MUM1/IRF4-IgH fusion in multiple myeloma.
Leukemia 13:1812-1816(1999)

DOI=10.1007/0-306-46877-8_4
Helena Jernberg-Wiklund, Kenneth Nilsson;
Multiple myeloma cell lines.
(In book chapter) Human cell culture. Vol. 3. Cancer cell lines part 3; Masters, John R.W. & Palsson, Bernhard Orn (eds.); pp.81-155; Kluwer Academic Publishers; New York; USA (2000)

PubMed=10936422; DOI=10.1016/S0145-2126(99)00195-2
Hans Gunther Drexler, Yoshinobu Matsuo;
Malignant hematopoietic cell lines: in vitro models for the study of multiple myeloma and plasma cell leukemia.
Leuk. Res. 24:681-703(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11157491; DOI=10.1182/blood.V97.3.729
Marta Chesi, Leslie A. Brents, Sarah A. Ely, Carlos Bais, Davide F. Robbiani, Enrique A. Mesri, Walter Michael Kuehl, Peter Leif Bergsagel;
Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma.
Blood 97:729-736(2001)

PubMed=11429052; DOI=10.1111/j.1349-7006.2001.tb01142.x; PMCID=PMC5926752
Ichiro Hanamura, Shinsuke Iida, Yumiko Akano, Yoshihito Hayami, Miyuki Kato, Kazuhisa Miura, Shinsuke Harada, Shogo Banno, Atsushi Wakita, Hitoshi Kiyoi, Tomoki Naoe ...Show all 16 authors... , Shiro Shimizu, Shin-ichi Sonta, Masakazu Nitta, Masafumi Taniwaki, Ryuzo Ueda; Show fewer authors
Ectopic expression of MAFB gene in human myeloma cells carrying (14;20)(q32;q11) chromosomal translocations.
Jpn. J. Cancer Res. 92:638-644(2001)

PubMed=12886255; DOI=10.1038/sj.leu.2403026
Yoshihito Hayami, S. Iida, Naozo Nakazawa, Ichiro Hanamura, M. Kato, H. Komatsu, Ikuo Miura, Bhavana J. Dave, Warren G. Sanger, B. Lim, Masafumi Taniwaki, R. Ueda;
Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma.
Leukemia 17:1650-1657(2003)

PubMed=17171682; DOI=10.1002/gcc.20404
Luigia Lombardi, Giulia Poretti, Michela Mattioli, Sonia Fabris, Luca Agnelli, Silvio Bicciato, Ivo Kwee, Andrea Rinaldi, Domenica Ronchetti, Donata Verdelli, Giorgio Lambertenghi-Deliliers ...Show all 13 authors... , Francesco Bertoni, Antonino Neri; Show fewer authors
Molecular characterization of human multiple myeloma cell lines by integrative genomics: insights into the biology of the disease.
Genes Chromosomes Cancer 46:226-238(2007)

PubMed=17229644; DOI=10.3324/haematol.10300
Takaomi Sanda, Shinsuke Iida, Satoshi Kayukawa, Ryuzo Ueda;
Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid.
Haematologica 92:115-120(2007)

PubMed=17692805; DOI=10.1016/j.ccr.2007.07.003; PMCID=PMC2083698
Jonathan J. Keats, Rafael Fonseca, Marta Chesi, Roelandt Schop, Angela Baker, Wee-Joo Chng, Scott Van Wier, Rodger Tiedemann, Chang-Xin Shi, Michael Sebag, Esteban Braggio ...Show all 30 authors... , Travis Henry, Yuan-Xiao Zhu, Homer Fogle, Tammy L. Price-Troska, Gregory J. Ahmann, Catherine Mancini, Leslie A. Brents, Shaji K. Kumar, Philip Robert Greipp, Angela Dispenzieri, Barb Bryant, George Mulligan, Laurakay Bruhn, Michael T. Barrett, Riccardo Valdez, Jeffrey M. Trent, A. Keith Stewart, John D. Carpten, Peter Leif Bergsagel; Show fewer authors
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.
Cancer Cell 12:131-144(2007)

PubMed=18647998; DOI=10.1093/jncimonographs/lgn011; PMCID=PMC2737184
Amel Dib, Ana Gabrea, Oleg K. Glebov, Peter Leif Bergsagel, Walter Michael Kuehl;
Characterization of MYC translocations in multiple myeloma cell lines.
J. Natl. Cancer Inst. Monogr. 39:25-31(2008)

PubMed=18700954; DOI=10.1186/1755-8794-1-37; PMCID=PMC2531129
Domenica Ronchetti, Marta Lionetti, Laura Mosca, Luca Agnelli, Adrian Andronache, Sonia Fabris, Giorgio Lambertenghi-Deliliers, Antonino Neri;
An integrative genomic approach reveals coordinated expression of intronic miR-335, miR-342, and miR-561 with deregulated host genes in multiple myeloma.
BMC Med. Genomics 1:37.1-37.9(2008)

PubMed=19306352; DOI=10.1002/gcc.20660
Marta Lionetti, Luca Agnelli, Laura Mosca, Sonia Fabris, Adrian Andronache, Katia Todoerti, Domenica Ronchetti, Giorgio Lambertenghi-Deliliers, Antonino Neri;
Integrative high-resolution microarray analysis of human myeloma cell lines reveals deregulated miRNA expression associated with allelic imbalances and gene expression profiles.
Genes Chromosomes Cancer 48:521-531(2009)

CLPUB00604
Sharon Chow;
Targeted capture and sequencing of immunoglobulin rearrangements in multiple myeloma to enable detection of minimal residual disease.
Thesis MSc (2017); University of Toronto; Toronto; Canada

PubMed=32123307; DOI=10.1038/s41375-020-0785-1; PMCID=PMC7483300
Vishesh Sarin, Katharine Yu, Ian D. Ferguson, Olivia Gugliemini, Matthew A. Nix, Byron Hann, Marina Sirota, Arun P. Wiita;
Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis.
Leukemia 34:2754-2765(2020)

Cross-references
Encyclopedic resources Wikidata; Q54835150
Gene expression databases GEO; GSM143352
GEO; GSM290289
Polymorphism and mutation databases Cosmic; 720785
Cosmic; 2081381
Cosmic; 2367267
Entry history
Entry creation05-Nov-2013
Last entry update14-Aug-2025
Version number21