• Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  
• Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  
• Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
  

PubMed=1622627; DOI=10.3109/02841869209088892
Anne E. Lykkesfeldt, E. Kirstine Sorensen;
Effect of estrogen and antiestrogens on cell proliferation and synthesis of secreted proteins in the human breast cancer cell line MCF-7 and a tamoxifen resistant variant subline, AL-1.
Acta Oncol. 31:131-138(1992)

PubMed=7664983; DOI=10.1016/0303-7207(95)03503-Y
Mogens W. Madsen, Birgit E. Reiter, Anne E. Lykkesfeldt;
Differential expression of estrogen receptor mRNA splice variants in the tamoxifen resistant human breast cancer cell line, MCF-7/TAMR-1 compared to the parental MCF-7 cell line.
Mol. Cell. Endocrinol. 109:197-207(1995)

PubMed=16172194; DOI=10.1677/erc.1.00946
Thomas Frogne, Jan Stenvang Jepsen, Soren S. Larsen, Cathrine Kolster Fog, Bettina Lundin Brockdorff, Anne E. Lykkesfeldt;
Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth.
Endocr. Relat. Cancer 12:599-614(2005)

PubMed=18824559; DOI=10.1677/ERC-07-0240
Sunil Pancholi, Anne E. Lykkesfeldt, Caroline Hilmi, Susana N. Banerjee, Alexandra Leary, Suzanne Drury, Stephen R.D. Johnston, Mitch Dowsett, Lesley-Ann Martin;
ERBB2 influences the subcellular localization of the estrogen receptor in tamoxifen-resistant MCF-7 cells leading to the activation of AKT and RPS6KA2.
Endocr. Relat. Cancer 15:985-1002(2008)

PubMed=25362855; DOI=10.1038/onc.2014.351
Susan Thrane, Astrid M. Pedersen, Mathilde Borg Houlberg Thomsen, Tove Kirkegaard, Birgitte Bruun Rasmussen, Anne Katrine Duun-Henriksen, Anne-Vibeke Laenkholm, Martin Bak, Anne E. Lykkesfeldt, Christina Westmose Yde;
A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells.
Oncogene 34:4199-4210(2015)