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Cellosaurus MCF-7/TAMR-1 (CVCL_M436)

[Text version]
Cell line name MCF-7/TAMR-1
Synonyms MCF7/TAMR-1; MCF7 TAMR-1; MCF-7/TAM(R)-1; MCF7-TAMR; TAMR-1; TamR-1; TamR1; AL-1
Accession CVCL_M436
Resource Identification Initiative To cite this cell line use: MCF-7/TAMR-1 (RRID:CVCL_M436)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:41774; Tamoxifen.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D47 (MCF-7/S0.5)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC101

Penta D12
Penta E7,12

Run an STR similarity search on this cell line

PubMed=1622627; DOI=10.3109/02841869209088892
Lykkesfeldt A.E., Sorensen E.K.
Effect of estrogen and antiestrogens on cell proliferation and synthesis of secreted proteins in the human breast cancer cell line MCF-7 and a tamoxifen resistant variant subline, AL-1.
Acta Oncol. 31:131-138(1992)

PubMed=7664983; DOI=10.1016/0303-7207(95)03503-Y
Madsen M.W., Reiter B.E., Lykkesfeldt A.E.
Differential expression of estrogen receptor mRNA splice variants in the tamoxifen resistant human breast cancer cell line, MCF-7/TAMR-1 compared to the parental MCF-7 cell line.
Mol. Cell. Endocrinol. 109:197-207(1995)

PubMed=16172194; DOI=10.1677/erc.1.00946
Frogne T., Jepsen J.S., Larsen S.S., Fog C.K., Brockdorff B.L., Lykkesfeldt A.E.
Antiestrogen-resistant human breast cancer cells require activated protein kinase B/Akt for growth.
Endocr. Relat. Cancer 12:599-614(2005)

PubMed=18824559; DOI=10.1677/ERC-07-0240
Pancholi S., Lykkesfeldt A.E., Hilmi C., Banerjee S., Leary A., Drury S., Johnston S.R.D., Dowsett M., Martin L.-A.
ERBB2 influences the subcellular localization of the estrogen receptor in tamoxifen-resistant MCF-7 cells leading to the activation of AKT and RPS6KA2.
Endocr. Relat. Cancer 15:985-1002(2008)

PubMed=25362855; DOI=10.1038/onc.2014.351
Thrane S., Pedersen A.M., Thomsen M.B.H., Kirkegaard T., Rasmussen B.B., Duun-Henriksen A.K., Laenkholm A.-V., Bak M., Lykkesfeldt A.E., Yde C.W.
A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells.
Oncogene 34:4199-4210(2015)

Cell line collections (Providers) CancerTools; 152089
Millipore; SCC101
Ximbio; 152089
Cell line databases/resources cancercelllines; CVCL_M436
Chemistry resources ChEMBL-Cells; CHEMBL4513115
Encyclopedic resources Wikidata; Q54904381
Entry history
Entry creation05-Nov-2013
Last entry update02-May-2024
Version number24