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Cellosaurus MCF-7/Taxol (CVCL_M355)

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Cell line name MCF-7/Taxol
Accession CVCL_M355
Resource Identification Initiative To cite this cell line use: MCF-7/Taxol (RRID:CVCL_M355)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=20926015; DOI=10.1177/147323001003800424
Ke-Qiang Zuo, Xiao-Ping Zhang, J. Zou, Dan Li, Zhong-Wei Lv;
Establishment of a paclitaxel resistant human breast cancer cell strain (MCF-7/Taxol) and intracellular paclitaxel binding protein analysis.
J. Int. Med. Res. 38:1428-1435(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M355
Encyclopedic resources Wikidata; Q54904387
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number18