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Cellosaurus XP1BR (CVCL_M285)

[Text version]
Cell line name XP1BR
Synonyms Xeroderma Pigmentosum 1 BRighton; GM03615; GM 3615; GM3615
Accession CVCL_M285
Resource Identification Initiative To cite this cell line use: XP1BR (RRID:CVCL_M285)
Comments Senescence: Senesces at 26 PDL (PubMed=6492896).
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Fibroblast of skin; CL=CL_0002620.
Sequence variations
Disease Xeroderma pigmentosum, complementation group D (NCIt: C3967)
Xeroderma pigmentosum (ORDO: Orphanet_910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 41Y
Category Finite cell line
STR profile Source(s): JCRB=JCRB3064

Markers:
AmelogeninX
CSF1PO11,12
D5S81810,11
D7S8208,9
D13S31710,12
D16S5399,12
TH019
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=7471106
Colin Francis Arlett, Susan A. Harcourt;
Survey of radiosensitivity in a variety of human cell strains.
Cancer Res. 40:926-932(1980)

PubMed=11219864; DOI=10.1093/carcin/1.9.745
Colin Francis Arlett, Susan A. Harcourt, Alan R. Lehmann, Sean Stevens, Malcolm Andrew Ferguson-Smith, W. Neil Morley;
Studies on a new case of xeroderma pigmentosum (XP3BR) from complementation group G with cellular sensitivity to ionizing radiation.
Carcinogenesis 1:745-751(1980)

PubMed=6947227; DOI=10.1073/pnas.78.10.6236; PMCID=PMC349013
Ruth Miskin, Ruth Ben-Ishai;
Induction of plasminogen activator by UV light in normal and xeroderma pigmentosum fibroblasts.
Proc. Natl. Acad. Sci. U.S.A. 78:6236-6240(1981)

PubMed=7059984
James Edward Cleaver;
Inactivation of ultraviolet repair in normal and xeroderma pigmentosum cells by methyl methanesulfonate.
Cancer Res. 42:860-863(1982)

PubMed=6492896; DOI=10.1016/0047-6374(84)90044-7
James Edward Cleaver;
DNA repair deficiencies and cellular senescence are unrelated in xeroderma pigmentosum cell lines.
Mech. Ageing Dev. 27:189-196(1984)

PubMed=4066782; DOI=10.1242/jcs.76.1.115
Robert T. Johnson, Shoshana Squires, George C. Elliott, Gordon L.E. Koch, Andrew J. Rainbow;
Xeroderma pigmentosum D-HeLa hybrids with low and high ultraviolet sensitivity associated with normal and diminished DNA repair ability, respectively.
J. Cell Sci. 76:115-133(1985)

PubMed=3347209; DOI=10.1016/0167-8817(88)90048-x
Shoshana Squires, Robert T. Johnson;
Kinetic analysis of UV-induced incision discriminates between fibroblasts from different xeroderma pigmentosum complementation groups, XPA heterozygotes and normal individuals.
Mutat. Res. 193:181-192(1988)

DOI=10.1007/978-1-4757-5016-4_9
Nicolaas G.J. Jaspers, Len Roza, Wim Vermeulen, Andre P.M. Eker, Rob Desire F.M. Taalman, Jan Hendrik Jozef Hoeijmakers, Dirk Bootsma;
In vitro correction of cells from patients with mutagen hypersensitivity.
(In book chapter) DNA damage and repair; Castellani, Amleto (eds.); pp.73-82; Springer; Boston; USA (1989)

CLPUB00447
Richard A. Mulivor, Sharon F. Suchy;
1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
(In misc. document) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda; USA (1992)

PubMed=1372108; DOI=10.1016/0921-8777(92)90072-b
Robert T. Johnson, Shoshana Squires;
The XPD complementation group. Insights into xeroderma pigmentosum, Cockayne's syndrome and trichothiodystrophy.
Mutat. Res. 273:97-118(1992)

PubMed=8055625; DOI=10.1093/carcin/15.8.1493
Mauro Mezzina, Eric Eveno, Odile Chevallier-Lagente, Annie Benoit, Madeleine Carreau, Wim Vermeulen, Jan Hendrik Jozef Hoeijmakers, Miria Stefanini, Alan R. Lehmann, Christine A. Weber, Alain Sarasin;
Correction by the ERCC2 gene of UV sensitivity and repair deficiency phenotype in a subset of trichothiodystrophy cells.
Carcinogenesis 15:1493-1498(1994)

PubMed=9012405; PMCID=PMC1712398
Geert Weeda, Eric Eveno, Ingrid Donker, Wim Vermeulen, Odile Chevallier-Lagente, Alain Taieb, Anne Stary, Jan Hendrik Jozef Hoeijmakers, Mauro Mezzina, Alain Sarasin;
A mutation in the XPB/ERCC3 DNA repair transcription gene, associated with trichothiodystrophy.
Am. J. Hum. Genet. 60:320-329(1997)

PubMed=9238033; DOI=10.1073/pnas.94.16.8658; PMCID=PMC23065
Elaine M. Taylor, Bernard C. Broughton, Elena Botta, Miria Stefanini, Alain Sarasin, Nicolaas G.J. Jaspers, Heather Fawcett, Susan A. Harcourt, Colin Francis Arlett, Alan R. Lehmann;
Xeroderma pigmentosum and trichothiodystrophy are associated with different mutations in the XPD (ERCC2) repair/transcription gene.
Proc. Natl. Acad. Sci. U.S.A. 94:8658-8663(1997)

PubMed=14688028; DOI=10.1093/carcin/bgh046
Stephane Arbault, Neso Sojic, Delphine Bruce, Christian Amatore, Alain Sarasin, Monique Vuillaume;
Oxidative stress in cancer prone xeroderma pigmentosum fibroblasts Real-time and single cell monitoring of superoxide and nitric oxide production with microelectrodes.
Carcinogenesis 25:509-515(2004)

PubMed=15572672; DOI=10.1128/mcb.24.24.10670-10680.2004; PMCID=PMC533987
Fabrizio Thorel, Angelos Constantinou, Isabelle Dunand-Sauthier, Thierry Nouspikel, Philippe Lalle, Anja Raams, Nicolaas G.J. Jaspers, Wim Vermeulen, Mahmud K.K. Shivji, Richard Dean Wood, Stuart Gordon Clarkson;
Definition of a short region of XPG necessary for TFIIH interaction and stable recruitment to sites of UV damage.
Mol. Cell. Biol. 24:10670-10680(2004)

PubMed=18079351; DOI=10.1259/bjr/27072321
Colin Francis Arlett, Michael H.L. Green, Paul Bryan Rogers, Alan R. Lehmann, Piers N. Plowman;
Minimal ionizing radiation sensitivity in a large cohort of xeroderma pigmentosum fibroblasts.
Br. J. Radiol. 81:51-58(2008)

Cross-references
Cell line collections (Providers) Coriell; GM03615
JCRB; JCRB3064
JCRB; KURB1067
JCRB; KURB1068 - Discontinued
Cell line databases/resources CLO; CLO_0017190
Encyclopedic resources Wikidata; Q54838158
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number21