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Cellosaurus POLZ KO (CVCL_M248)

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Cell line name POLZ KO
Synonyms Nalm-6-MSH+/REV3L-/-
Accession CVCL_M248
Resource Identification Initiative To cite this cell line use: POLZ KO (RRID:CVCL_M248)
Comments Population: Caucasian.
Knockout cell: Method=Homologous recombination; HGNC; HGNC:9968; REV3L.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:7325; MSH2 (Note=Exons 9 to 16).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:50800; DUX4 + HGNC; HGNC:5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line).
Disease Adult B acute lymphoblastic leukemia (NCIt: C9143)
Precursor B-cell acute lymphoblastic leukemia (ORDO: Orphanet_99860)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_J365 (Nalm-6-MSH+)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1488

Markers:
AmelogeninX,Y
CSF1PO14
D5S81811,13
D7S8208,12
D13S3179,13
D16S5399,11
TH018,9
TPOX8,10
vWA15,16

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Cross-references
Cell line collections (Providers) JCRB; JCRB1488
Cell line databases/resources cancercelllines; CVCL_M248
Encyclopedic resources Wikidata; Q54947737
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number19