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Cellosaurus HLF-R4 (CVCL_M181)

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Cell line name HLF-R4
Accession CVCL_M181
Resource Identification Initiative To cite this cell line use: HLF-R4 (RRID:CVCL_M181)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_46345; 5-fluorouracil (5-FU).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Cell type: Fibroblast; CL=CL_0000057.
Sequence variations
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly244Ala (c.731G>C); ClinVar=VCV000458560; Zygosity=Unspecified (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2947 (HLF)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
Publications

PubMed=22179686; DOI=10.3892/ijo.2011.1300; PMCID=PMC3584526
Kazuya Uchibori, Atsushi Kasamatsu, Masahiko Sunaga, Satoshi Yokota, Tomoya Sakurada, Eriko Kobayashi, Masaharu Yoshikawa, Katsuhiro Uzawa, Shiro Ueda, Hideki Tanzawa, Nobunori Sato;
Establishment and characterization of two 5-fluorouracil-resistant hepatocellular carcinoma cell lines.
Int. J. Oncol. 40:1005-1010(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M181
Encyclopedic resources Wikidata; Q54889854
Entry history
Entry creation06-May-2013
Last entry update19-Dec-2024
Version number16