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Cellosaurus HKCI-4 (CVCL_M175)

[Text version]
Cell line name HKCI-4
Accession CVCL_M175
Resource Identification Initiative To cite this cell line use: HKCI-4 (RRID:CVCL_M175)
Comments Population: Chinese.
Virology: Expresses chimeric hepatitis B virus (HBV)-human transcripts (PubMed=24582836).
Karyotypic information: Has lost chromosome Y.
Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=11793441; DOI=10.1002/gcc.1220
Elizabeth Pang, Nathalie Wong, Paul Bo-San Lai, Ka-Fai To, Joseph Wan-Yee Lau, Philip James Johnson;
Consistent chromosome 10 rearrangements in four newly established human hepatocellular carcinoma cell lines.
Genes Chromosomes Cancer 33:150-159(2002)

DOI=10.1385/CP:1:3-4:313
Ronald Ting-Kai Pang, Terence Chuen-Wai Poon, Nathalie Wong, Paul Bo-San Lai, Navy L.-Y. Wong, Charles M.-L. Chan, Jasmine W.S. Yu, Anthony Tak-Cheung Chan, Joseph Jao-Yiu Sung;
Comparison of protein expression patterns between hepatocellular carcinoma cell lines and a hepatoblastoma cell line.
Clin. Proteomics 1:313-331(2004)

PubMed=15645427; DOI=10.1002/ijc.20684
Kathy Y.-Y. Chan, Nathalie Wong, Paul Bo-San Lai, Jeremy Andrew Squire, Pascale F. Macgregor, Ben Beheshti, Monique Albert, Ka-Fai To, Philip James Johnson;
Transcriptional profiling on chromosome 19p indicated frequent downregulation of ACP5 expression in hepatocellular carcinoma.
Int. J. Cancer 114:902-908(2005)

PubMed=15709204; DOI=10.1158/1078-0432.1319.11.3
Nathalie Wong, Kathy Y.-Y. Chan, Pascale F. Macgregor, Paul Bo-San Lai, Jeremy Andrew Squire, Ben Beheshti, Monique Albert, Thomas Wai-Tong Leung;
Transcriptional profiling identifies gene expression changes associated with IFN-alpha tolerance in hepatitis C-related hepatocellular carcinoma cells.
Clin. Cancer Res. 11:1319-1326(2005)

PubMed=15765123; DOI=10.1038/labinvest.3700254
Elizabeth Pang, Ying Hu, Kathy Y.-Y. Chan, Paul Bo-San Lai, Jeremy Andrew Squire, Pascale F. Macgregor, Ben Beheshti, Monique Albert, Thomas Wai-Tong Leung, Nathalie Wong;
Karyotypic imbalances and differential gene expressions in the acquired doxorubicin resistance of hepatocellular carcinoma cells.
Lab. Invest. 85:664-674(2005)

PubMed=19003983; DOI=10.1002/ijc.23968
Nathalie Wong, Winnie Yeo, Wai-Lap Wong, Navy L.-Y. Wong, Kathy Y.-Y. Chan, Frankie K.-F. Mo, Jane Koh, Stephan Lam Chan, Anthony Tak-Cheung Chan, Paul Bo-San Lai, Arthur K.-K. Ching ...Show all 15 authors... , Joanna H.-M. Tong, Ho-Keung Ng, Philip James Johnson, Ka-Fai To; Show fewer authors
TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance.
Int. J. Cancer 124:644-652(2009)

PubMed=23376363; DOI=10.1016/j.jhep.2013.01.032
Priscilla T.-Y. Law, Hao Qin, Arthur K.-K. Ching, Keng Po Lai, Ngai Na Co, Mian He, Raymond W.-M. Lung, Anthony W.-H. Chan, Ting-Fung Chan, Nathalie Wong;
Deep sequencing of small RNA transcriptome reveals novel non-coding RNAs in hepatocellular carcinoma.
J. Hepatol. 58:1165-1173(2013)

PubMed=24582836; DOI=10.1016/j.ccr.2014.01.030
Chi-Chiu Lau, Ting-Ting Sun, Arthur K.-K. Ching, Mian He, Jing-Woei Li, Alissa M. Wong, Ngai Na Co, Anthony W.-H. Chan, Pik-Shan Li, Raymond W.-M. Lung, Joanna H.-M. Tong ...Show all 16 authors... , Paul Bo-San Lai, Henry L.-Y. Chan, Ka-Fai To, Ting-Fung Chan, Nathalie Wong; Show fewer authors
Viral-human chimeric transcript predisposes risk to liver cancer development and progression.
Cancer Cell 25:335-349(2014)

Cross-references
Encyclopedic resources Wikidata; Q54889754
Sequence databases EGA; EGAD00001004475
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number14