Cellosaurus cell line HC-AFW1 (CVCL

Cellosaurus HC-AFW1 (CVCL_M172)

Cross-references
Cell line name	HC-AFW1
Synonyms	HCAFW1
Accession	CVCL_M172
Resource Identification Initiative	To cite this cell line use: HC-AFW1 (RRID:CVCL_M172)
Comments	Doubling time: 40 hours (PubMed=22666492). Omics: Variations; CNV analysis.
Sequence variations	Gene deletion; HGNC; HGNC:2625; CYP2D6; Zygosity=Heterozygous (PubMed=26310804). Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Val22_Phe70del; Zygosity=Heterozygous (PubMed=22666492).
Disease	Childhood hepatocellular carcinoma (NCIt: C7955) Pediatric hepatocellular carcinoma (ORDO: Orphanet_33402)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Male
Age at sampling	4Y6M
Category	Cancer cell line
Publications	PubMed=22666492; DOI=10.1371/journal.pone.0038223; PMCID=PMC3364222 Sorin Armeanu-Ebinger, Julia Wenz, Guido Seitz, Ivo Leuschner, Rupert Handgretinger, Ulrike A. Mau-Holzmann, Michael Bonin, Bence Sipos, Jorg Fuchs, Steven W. Warmann; Characterisation of the cell line HC-AFW1 derived from a pediatric hepatocellular carcinoma. PLoS ONE 7:e38223.1-e38223.10(2012) PubMed=26310804; DOI=10.1124/dmd.115.064667 Albert Braeuning, Maria Thomas, Ute Hofmann, Silvia Vetter, Eva Zeller, Barbara Petzuch, Janina Johanning, Werner Schroth, Thomas S. Weiss, Ulrich M. Zanger, Michael Schwarz; Comparative analysis and functional characterization of HC-AFW1 hepatocarcinoma cells: cytochrome P450 expression and induction by nuclear receptor agonists. Drug Metab. Dispos. 43:1781-1787(2015)
Cell line databases/resources	cancercelllines; CVCL_M172
Encyclopedic resources	Wikidata; Q54881474
Gene expression databases	GEO; GSE29283
Polymorphism and mutation databases	Progenetix; CVCL_M172
Entry history
Entry creation	06-May-2013
Last entry update	10-Apr-2025
Version number	16