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Cellosaurus BT-12 (CVCL_M155)

[Text version]
Cell line name BT-12
Synonyms BT 12; BT12
Accession CVCL_M155
Resource Identification Initiative To cite this cell line use: BT-12 (RRID:CVCL_M155)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
From: Biegel, Jaclyn A.; Children's Hospital of Philadelphia; Philadelphia; USA.
Population: Caucasian.
Doubling time: 27 hours (PubMed=20922763).
Omics: Genomics; Whole exome sequencing.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Brain, posterior fossa; UBERON=UBERON_0008788.
Disease Atypical teratoid/rhabdoid tumor (NCIt: C6906)
Atypical teratoid rhabdoid tumor (ORDO: Orphanet_99966)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 2M
Category Cancer cell line
STR profile Source(s): COG; PubMed=20922763

Markers:
AmelogeninX
CSF1PO10,12
D2S133823
D3S135815,16
D5S81812
D7S8209,12
D8S117913,15
D13S31711,13
D16S53911,12
D18S5113,14
D19S43312,14
D21S1129,33.2
FGA22
TH017,9
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Web pages Provider; CCR; -; https://www.cccells.org/PDF_Files/Brain/BT-12.pdf
Provider; CCR; -; https://www.cccells.org/tables/Brain.php
Publications

PubMed=17446062; DOI=10.1016/j.ejca.2007.03.003
Jaya D'cunja, Tarek Shalaby, Paola Rivera, Andre O. von Bueren, Ratnakar Patti, Frank L. Heppner, Alexandre Arcaro, Lucy Balian Rorke-Adams, Peter C. Phillips, Michael A. Grotzer;
Antisense treatment of IGF-IR induces apoptosis and enhances chemosensitivity in central nervous system atypical teratoid/rhabdoid tumours cells.
Eur. J. Cancer 43:1581-1589(2007)

PubMed=20922763; DOI=10.1002/pbc.22801; PMCID=PMC3005554
Min H. Kang, Malcolm A. Smith, Christopher L. Morton, Nino Keshelava, Peter J. Houghton, Charles Patrick Reynolds;
National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
Pediatr. Blood Cancer 56:239-249(2011)

PubMed=22206574; DOI=10.1186/1475-2867-11-44; PMCID=PMC3278350
Aarthi A. Jayanthan, Delphine Bernoux, Pinaki Bose, Karl Thomas Riabowol, Aru Narendran;
Multi-tyrosine kinase inhibitors in preclinical studies for pediatric CNS AT/RT: evidence for synergy with topoisomerase-I inhibition.
Cancer Cell Int. 11:44.1-44.11(2011)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M155
Cell_Model_Passport; SIDM01514
DepMap; ACH-000160
Biological sample resources BioSample; SAMN10989598
Chemistry resources PharmacoDB; BT12_113_2019
Encyclopedic resources Wikidata; Q54798448
Gene expression databases GEO; GSM3145596
GEO; GSM3145691
Entry history
Entry creation06-May-2013
Last entry update14-Aug-2025
Version number20