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Cellosaurus CHLA-25 (CVCL_M152)

[Text version]
Cell line name CHLA-25
Synonyms CHLA25
Accession CVCL_M152
Resource Identification Initiative To cite this cell line use: CHLA-25 (RRID:CVCL_M152)
Comments Doubling time: 99 hours (PubMed=24312454).
Omics: Transcriptome analysis by RNAseq.
Sequence variations
  • Gene fusion; HGNC; 3446; ERG + HGNC; 3508; EWSR1; Name(s)=EWSR1-ERG, EWS-ERG (PubMed=25010205).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Unspecified (PubMed=25010205).
Disease Primitive neuroectodermal tumor (NCIt: C3716)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_A444 ! TTC-466
Sex of cell Female
Age at sampling 2Y7M
Category Cancer cell line
STR profile Source(s): COG; PubMed=24312454; PubMed=25010205

Markers:
AmelogeninX
CSF1PO10
D2S133819,22
D3S135817,18
D5S81810
D7S8208,10
D8S117913,15
D13S31710,12
D16S53911,12
D18S5114,17
D19S43314
D21S1129,32.2
FGA24,25
TH017
TPOX8
vWA15,17

Run an STR similarity search on this cell line
Web pages https://www.cccells.org/PDF_Files/Ewings/CHLA-25%20Cell%20Line%20Data%20Sheet.pdf
https://www.cccells.org/tables/Ewings.php
Publications

PubMed=24312454; DOI=10.1371/journal.pone.0080060
May W.A., Grigoryan R.S., Keshelava N., Cabral D.J., Christensen L.L., Jenabi J., Ji L.-Y., Triche T.J., Lawlor E.R., Reynolds C.P.
Characterization and drug resistance patterns of Ewing's sarcoma family tumor cell lines.
PLoS ONE 8:E80060-E80060(2013)

PubMed=25010205; DOI=10.1371/journal.pgen.1004475
Brohl A.S., Solomon D.A., Chang W., Wang J.-J., Song Y., Sindiri S., Patidar R., Hurd L., Chen L., Shern J.F., Liao H.-L., Wen X.-Y., Gerard J., Kim J.-S., Lopez Guerrero J.A., Machado I., Wai D.H., Picci P., Triche T.J., Horvai A.E., Miettinen M.M., Wei J.S., Catchpoole D., Llombart-Bosch A., Waldman T., Khan J.
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:E1004475-E1004475(2014)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

DOI=10.5282/edoc.27750
Orth M.F.
Systematic multi-omics profiling of Ewing sarcoma cell lines.
Thesis PhD (2021), Ludwig Maximilians University of Munich, Germany

Cross-references
Cell line databases/resources cancercelllines; CVCL_M152
Encyclopedic resources Wikidata; Q54812489
Gene expression databases GEO; GSM1676353
GEO; GSM1701683
Polymorphism and mutation databases Cosmic; 2228216
Entry history
Entry creation06-May-2013
Last entry update05-Oct-2023
Version number16