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Cellosaurus CHLA-32 (CVCL_M151)

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Cell line name CHLA-32
Synonyms CHLA32
Accession CVCL_M151
Resource Identification Initiative To cite this cell line use: CHLA-32 (RRID:CVCL_M151)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Doubling time: 26 hours (PubMed=24312454).
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Transcriptomics; RNAseq.
Sequence variations
  • Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (PubMed=25010205).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg342Ter (c.1024C>T); ClinVar=VCV000182970; Zygosity=Unspecified (PubMed=25010205; DepMap=ACH-001032).
Disease Primitive neuroectodermal tumor (NCIt: C3716)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 8Y6M
Category Cancer cell line
STR profile Source(s): COG; PubMed=24312454; PubMed=25010205

Markers:
AmelogeninX
CSF1PO10,11 (PubMed=24312454)
11 (COG; PubMed=25010205)
D2S133824
D3S135816
D5S81811
D7S8208,9
D8S117913,15
D13S31712
D16S53912
D18S5118,19 (PubMed=24312454)
19 (COG; PubMed=25010205)
D19S43313,15
D21S1128,31
FGA24
TH016,9.3
TPOX8,10
vWA16,17

Run an STR similarity search on this cell line
Web pages Provider; CCR; -; https://www.cccells.org/PDF_Files/Ewings/CHLA-32%20Cell%20Line%20Data%20Sheet.pdf
Provider; CCR; -; https://www.cccells.org/tables/Ewings.php
Publications

PubMed=15289350; DOI=10.1158/0008-5472.CAN-04-0377
Sandeep Batra, Charles Patrick Reynolds, Barry J. Maurer;
Fenretinide cytotoxicity for Ewing's sarcoma and primitive neuroectodermal tumor cell lines is decreased by hypoxia and synergistically enhanced by ceramide modulators.
Cancer Res. 64:5415-5424(2004)

PubMed=24312454; DOI=10.1371/journal.pone.0080060; PMCID=PMC3846563
William A. May, Rita S. Grigoryan, Nino Keshelava, Daniel J. Cabral, Laura L. Christensen, Jasmine Jenabi, Ling-Yun Ji, Timothy J. Triche, Elizabeth R. Lawlor, Charles Patrick Reynolds;
Characterization and drug resistance patterns of Ewing's sarcoma family tumor cell lines.
PLoS ONE 8:e80060.1-e80060.10(2013)

PubMed=25010205; DOI=10.1371/journal.pgen.1004475; PMCID=PMC4091782
Andrew S. Brohl, David A. Solomon, Wendy Chang, Jian-Jun Wang, Young Song, Sivasish Sindiri, Rajesh Patidar, Laura Hurd, Li Chen, Jack F. Shern, Hong-Ling Liao ...Show all 26 authors... , Xin-Yu Wen, Julia Gerard, Jung-Sik Kim, Jose Antonio Lopez-Guerrero, Isidro Machado, Daniel H. Wai, Piero Picci, Timothy J. Triche, Andrew E. Horvai, Markku Martti Miettinen, Jun S. Wei, Daniel Catchpoole, Antonio Llombart-Bosch, Todd A. Waldman, Javed Khan; Show fewer authors
The genomic landscape of the Ewing sarcoma family of tumors reveals recurrent STAG2 mutation.
PLoS Genet. 10:e1004475.1-e1004475.13(2014)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476
Beverly A. Teicher, Eric C. Polley, Mark W. Kunkel, David Evans, Thomas E. Silvers, Rene M. Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Michael Selby, John Connelly ...Show all 14 authors... , Erik Harris, Anne Monks, Joel Morris; Show fewer authors
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M151
Cell_Model_Passport; SIDM01536
DepMap; ACH-001032
Encyclopedic resources Wikidata; Q54812497
Gene expression databases GEO; GSM1676355
GEO; GSM1701685
Polymorphism and mutation databases Cosmic; 2228218
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number22