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Cellosaurus LNCaP C5 (CVCL_M132)

[Text version]
Cell line name LNCaP C5
Synonyms LNCaP-C5; LNCaP subline C5; C5
Accession CVCL_M132
Resource Identification Initiative To cite this cell line use: LNCaP C5 (RRID:CVCL_M132)
Comments Population: Caucasian.
Characteristics: Derived from a tumor that developed in castrated nude mice injected with LNCaP cells.
Derived from site: Metastatic; Left supraclavicular lymph node; UBERON=UBERON_8480056.
Sequence variations
  • Mutation; HGNC; 644; AR; Simple; p.Thr878Ala (c.2632A>G); ClinVar=VCV000009831; Zygosity=Hemizygous (from parent cell line).
  • Mutation; HGNC; 7010; MEN1; Simple; p.Tyr318Ter (c.954T>G) (p.Tyr313Ter, c.939T>A); ClinVar=VCV000439894; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8979; PIK3R1; Simple; p.Arg639Ter (c.1915C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys6Argfs*4 (c.17_18delAA); ClinVar=VCV000231649; Zygosity=Unspecified (from parent cell line).
Disease Prostate carcinoma (NCIt: C4863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0395 (LNCaP)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
Web pages https://en.wikipedia.org/wiki/LNCaP

PubMed=8169003; DOI=10.1002/ijc.2910570319
Wu H.-C., Hsieh J.-T., Gleave M.E., Brown N.M., Pathak S., Chung L.W.K.
Derivation of androgen-independent human LNCaP prostatic cancer cell sublines: role of bone stromal cells.
Int. J. Cancer 57:406-412(1994)

PubMed=35502546; DOI=10.1158/0008-5472.CAN-22-1065
Abate-Shen C., Nunes de Almeida F.
Establishment of the LNCaP cell line -- the dawn of an era for prostate cancer research.
Cancer Res. 82:1689-1691(2022)

Cell line databases/resources cancercelllines; CVCL_M132
Encyclopedic resources Wikidata; Q54902822
Entry history
Entry creation06-May-2013
Last entry update05-Oct-2023
Version number17