Cellosaurus logo
expasy logo

Cellosaurus RPCI-WM1 (CVCL_M087)

[Text version]
Cell line name RPCI-WM1
Synonyms Roswell Park Cancer Institute-Waldenstrom Macroglobulinemia 1
Accession CVCL_M087
Resource Identification Initiative To cite this cell line use: RPCI-WM1 (RRID:CVCL_M087)
Comments Doubling time: ~34 hours (PubMed=22812491).
Omics: Genomics; Whole genome sequencing.
Derived from site: In situ; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:7562; MYD88; Simple; p.Leu252Pro (c.755T>C) (p.Leu265Pro, c.794T>C) (L265P); ClinVar=VCV000037055; Zygosity=Heterozygous (PubMed=22812491).
Disease Waldenstrom macroglobulinemia (NCIt: C80307)
Waldenstrom macroglobulinemia (ORDO: Orphanet_33226)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_VJ33 (RPCI-WM1/IR)
Sex of cell Female
Age at sampling 48Y
Category Cancer cell line
Publications

PubMed=22812491; DOI=10.3109/10428194.2012.713481; PMCID=PMC4406272
Kasyapa S. Chitta, Aneel Paulus, Sikander Ailawadhi, Barbara A. Foster, Michael T. Moser, Petr Starostik, Aisha Masood, Taimur Sher, Kena C. Miller, Dan M. Iancu, Jeffrey Conroy ...Show all 20 authors... , Norma Jean Nowak, Sheila N. Jani Sait, David Alva Personett, Morton Coleman, Richard R. Furman, Peter Martin, Stephen M. Ansell, Kelvin Lee, Asher A. Chanan-Khan; Show fewer authors
Development and characterization of a novel human Waldenstrom macroglobulinemia cell line: RPCI-WM1, Roswell Park Cancer Institute -- Waldenstrom Macroglobulinemia 1.
Leuk. Lymphoma 54:387-396(2013)

PubMed=22950966; DOI=10.3109/10428194.2012.727418
Hans Gunther Drexler, Su-Ning Chen, Roderick A.F. MacLeod;
Would the real Waldenstrom cell line please stand up?
Leuk. Lymphoma 54:224-226(2013)

PubMed=25853860; DOI=10.1371/journal.pone.0122338; PMCID=PMC4390194
Aneel Paulus, Kasyapa S. Chitta, Paul K. Wallace, Pooja P. Advani, Sharoon Akhtar, Maja Kristin Kuranz Blake, Sikander Ailawadhi, Asher A. Chanan-Khan;
Immunophenotyping of Waldenstroms macroglobulinemia cell lines reveals distinct patterns of surface antigen expression: potential biological and therapeutic implications.
PLoS ONE 10:e0122338.1-e0122338.17(2015)

PubMed=28548645; DOI=10.1038/bcj.2017.40; PMCID=PMC5518884
Aneel Paulus, Sharoon Akhtar, Hafiz Muhammad Yousaf, Alak Manna, Shumail Marshal Paulus, Yamima Bashir, Thomas R. Caulfield, Maja Kristin Kuranz Blake, Kasyapa S. Chitta, Xue Wang, Yan Asmann ...Show all 15 authors... , Roman Hudec, Wolfdieter Springer, Sikander Ailawadhi, Asher A. Chanan-Khan; Show fewer authors
Waldenstrom macroglobulinemia cells devoid of BTK(C481S) or CXCR4(WHIM-like) mutations acquire resistance to ibrutinib through upregulation of Bcl-2 and AKT resulting in vulnerability towards venetoclax or MK2206 treatment.
Blood Cancer J. 7:e565.1-e565.11(2017)

PubMed=40254718; DOI=10.1111/bjh.20072
Shi-Rong Liu, Xia Liu, Choudhury Fabliha Binte Yusuf, Amanda Kofides, Kara M. Soroko, Johany Penailillo, Alexa G. Canning, Yang Cao, Guang Yang, Lian Xu, Nicholas Tsakmaklis ...Show all 22 authors... , Hao Sun, Alberto Guijosa, Maria Luisa Guerrera, Christopher J. Patterson, Ruben D. Carrasco, Prafulla C. Gokhale, Shayna Rae Sarosiek, Jorge J. Castillo, John M. Hatcher, Zachary Richard Hunter, Steven Peter Treon; Show fewer authors
Development and characterization of the novel MYD88 mutated, 6q deleted BCWM.2 cell line for Waldenstrom macroglobulinaemia.
Br. J. Haematol. 206:1604-1614(2025)

Cross-references
Cell line databases/resources cancercelllines; CVCL_M087
Encyclopedic resources Wikidata; Q54951135
Polymorphism and mutation databases Cosmic; 2645646
Entry history
Entry creation06-May-2013
Last entry update14-Aug-2025
Version number19