Cellosaurus cell line MCC-60 (CVCL

Cellosaurus MCC-60 (CVCL_LM85)

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Cell line name

MCC-60

Synonyms

P3-CL; CL3

Accession

CVCL_LM85

Secondary accession

CVCL_A1QM

Resource Identification Initiative

To cite this cell line use: MCC-60 (RRID:CVCL_LM85)

Comments

Population: Caucasian.
Doubling time: 42 hours (PubMed=33087752); ~70-80 hours (DSMZ=ACC-815).
Omics: Variations; Array-based CGH.
Derived from site: In situ; Colon, ascending; UBERON=UBERON_0001156.

Sequence variations

Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=33087752).
Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465His (c.1394G>A); ClinVar=VCV000376415; Zygosity=Heterozygous (PubMed=33087752).
Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Heterozygous (PubMed=33087752).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg267Trp (c.799C>T); ClinVar=VCV000141764; Zygosity=Heterozygous (PubMed=33087752).
Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro301Glnfs*44 (c.902delC); ClinVar=VCV000233908; Zygosity=Heterozygous (PubMed=33087752).

Disease

Colon adenocarcinoma (NCIt: C4349)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell

Male

Age at sampling

65Y

Category

Cancer cell line

STR profile

Source(s): DSMZ=ACC-815; PubMed=33087752

Markers:

Amelogenin	X,Y
CSF1PO	9,12 (DSMZ=ACC-815) 11,12 (PubMed=33087752)
D2S1338	17,24
D3S1358	13,18,19
D5S818	11,13
D7S820	9.3,10.3,13 (PubMed=33087752) 12 (DSMZ=ACC-815)
D8S1179	11,13
D13S317	10 (DSMZ=ACC-815) 13 (PubMed=33087752)
D16S539	8,14
D18S51	17,19
D19S433	13,14
D21S11	33,34
FGA	19,20,22.2
Penta D	12,14
Penta E	16
TH01	7,8,9 (PubMed=33087752) 7,9 (DSMZ=ACC-815)
TPOX	8 (DSMZ=ACC-815) 8,11 (PubMed=33087752)
vWA	13,18 (PubMed=33087752) 14,18 (DSMZ=ACC-815)

Publications

PubMed=33087752; DOI=10.1038/s41598-020-74797-0; PMCID=PMC7578805
Daniela Hirsch, Steffen Seyfried, Tobias Staib, David Fiedler, Christian Sauer, Thomas Ried, Stephanie Witt, Felix Rueckert, Timo Gaiser;
Newly established gastrointestinal cancer cell lines retain the genomic and immunophenotypic landscape of their parental cancers.
Sci. Rep. 10:17895.1-17895.11(2020)

Cross-references

Cell line collections (Providers)

DSMZ; ACC-815

Cell line databases/resources

cancercelllines; CVCL_LM85
DSMZCellDive; ACC-815

Encyclopedic resources

Wikidata; Q54904248

Gene expression databases

GEO; GSM4563057

Entry history

Entry creation

15-Nov-2017

Last entry update

10-Apr-2025

Version number