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Cellosaurus UROtsa As#5 (CVCL_LM63)

[Text version]
Cell line name UROtsa As#5
Synonyms UT As #5
Accession CVCL_LM63
Resource Identification Initiative To cite this cell line use: UROtsa As#5 (RRID:CVCL_LM63)
Comments Characteristics: Tumorigenic derivative of UROtsa. Subcutaneous injection of this cell line in nude mice produces tumors.
Doubling time: 16.4 +- 0.7 hours (PubMed=20186695).
Transformant: ChEBI; CHEBI_29678; Sodium arsenite.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Urinary bladder, urothelium; UBERON=UBERON_0004645.
Cell type: Urothelial cell; CL=CL_0000731.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 12Y
Category Transformed cell line
Publications

PubMed=20186695; DOI=10.1002/jat.1513; PMCID=PMC3100548
Cao L., Zhou X.-D., Sens M.A., Garrett S.H., Zheng Y., Dunlevy J.R., Sens D.A., Somji S.
Keratin 6 expression correlates to areas of squamous differentiation in multiple independent isolates of As(+3)-induced bladder cancer.
J. Appl. Toxicol. 30:416-430(2010)

PubMed=30550540; DOI=10.1371/journal.pone.0207877; PMCID=PMC6294394
Hoggarth Z.E., Osowski D.B., Freeberg B.A., Garrett S.H., Sens D.A., Sens M.A., Zhou X.-D., Zhang K.K., Somji S.
The urothelial cell line UROtsa transformed by arsenite and cadmium display basal characteristics associated with muscle invasive urothelial cancers.
PLoS ONE 13:e0207877.1-e0207877.26(2018)

Cross-references
Encyclopedic resources Wikidata; Q54991820
Entry history
Entry creation15-Nov-2017
Last entry update19-Dec-2024
Version number8