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Cellosaurus UROtsa As#2 (CVCL_LM60)

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Cell line name UROtsa As#2
Synonyms UT As #2
Accession CVCL_LM60
Resource Identification Initiative To cite this cell line use: UROtsa As#2 (RRID:CVCL_LM60)
Comments Characteristics: Tumorigenic derivative of UROtsa. Subcutaneous injection of this cell line in nude mice produces tumors.
Doubling time: 14.1 +- 0.9 hours (PubMed=20186695).
Transformant: ChEBI; CHEBI_29678; Sodium arsenite.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Derived from site: In situ; Urinary bladder, urothelium; UBERON=UBERON_0004645.
Cell type: Urothelial cell; CL=CL_0000731.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0571 (UROtsa)
Sex of cell Female
Age at sampling 12Y
Category Transformed cell line
Publications

PubMed=20186695; DOI=10.1002/jat.1513; PMCID=PMC3100548
Ling Cao, Xu-Dong Zhou, Mary Ann Sens, Scott H. Garrett, Yun Zheng, Jane R. Dunlevy, Donald A. Sens, Seema Somji;
Keratin 6 expression correlates to areas of squamous differentiation in multiple independent isolates of As(+3)-induced bladder cancer.
J. Appl. Toxicol. 30:416-430(2010)

PubMed=30550540; DOI=10.1371/journal.pone.0207877; PMCID=PMC6294394
Zachary E. Hoggarth, Danyelle B. Osowski, Brooke Alexandra Freeberg, Scott H. Garrett, Donald A. Sens, Mary Ann Sens, Xu-Dong Zhou, Ke K. Zhang, Seema Somji;
The urothelial cell line UROtsa transformed by arsenite and cadmium display basal characteristics associated with muscle invasive urothelial cancers.
PLoS ONE 13:e0207877.1-e0207877.26(2018)

Cross-references
Encyclopedic resources Wikidata; Q54991808
Entry history
Entry creation15-Nov-2017
Last entry update27-Nov-2025
Version number9