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Cellosaurus HATL (CVCL_LI16)

[Text version]
Cell line name HATL
Accession CVCL_LI16
Resource Identification Initiative To cite this cell line use: HATL (RRID:CVCL_LI16)
Comments Population: Caucasian.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175Pro (c.524G>C); Zygosity=Heterozygous (PubMed=8486778).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_LI15 ! HABL
Sex of cell Female
Age at sampling 10Y
Category Cancer cell line
Publications

PubMed=8486778; DOI=10.1172/JCI116435; PMCID=PMC288211
Jo Yeargin, Jian Cheng, Alice Lin-Tsing Yu, Ruth A. Gjerset, Mark Bogart, Martin Haas;
p53 mutation in acute T cell lymphoblastic leukemia is of somatic origin and is stable during establishment of T cell acute lymphoblastic leukemia cell lines.
J. Clin. Invest. 91:2111-2117(1993)

PubMed=10637496; DOI=10.1038/sj.leu.2401604
Hans Gunther Drexler, Severine Fombonne, Yoshinobu Matsuo, Z.-B. Hu, Hiroyuki Hamaguchi, Cord C. Uphoff;
p53 alterations in human leukemia-lymphoma cell lines: in vitro artifact or prerequisite for cell immortalization?
Leukemia 14:198-206(2000)

Cross-references
Encyclopedic resources Wikidata; Q54881331
Entry history
Entry creation15-Nov-2017
Last entry update19-Dec-2024
Version number9