Cellosaurus cell line RKO EGFR (T790M/+) (CVCL

Cellosaurus RKO EGFR (T790M/+) (CVCL_LD10)

Cross-references
Cell line name	RKO EGFR (T790M/+)
Synonyms	EGFR (T790M/+) RKO
Accession	CVCL_LD10
Resource Identification Initiative	To cite this cell line use: RKO EGFR (T790M/+) (RRID:CVCL_LD10)
Comments	Characteristics: Heterozygous knockin of a EGFR mutation conferring drug resistance. Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations	Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:3236; EGFR; Simple_edited; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Heterozygous; Note=By method not specified (Horizon_Discovery=HD+106-005). Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line). Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
Disease	Colon carcinoma (NCIt: C4910)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0504 (RKO)
Sex of cell	Sex unspecified
Age at sampling	Age unspecified
Category	Cancer cell line
Cell line collections (Providers)	Horizon_Discovery; HD+106-005
Cell line databases/resources	cancercelllines; CVCL_LD10
Encyclopedic resources	Wikidata; Q54950548
Entry history
Entry creation	22-Aug-2017
Last entry update	19-Dec-2024
Version number	12