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Cellosaurus RKO EGFR (C240Y/+) (CVCL_LD06)

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Cell line name RKO EGFR (C240Y/+)
Synonyms EGFR (C240Y/+) RKO
Accession CVCL_LD06
Resource Identification Initiative To cite this cell line use: RKO EGFR (C240Y/+) (RRID:CVCL_LD06)
Comments Characteristics: Heterozygous knockin of a EGFR mutation.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple_edited; p.Cys240Tyr (c.719G>A); Zygosity=Heterozygous; Note=By method not specified (Horizon_Discovery=HD+106-022).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11773; TGFBR2; Simple; p.Leu452Pro (c.1355T>C); ClinVar=VCV000930524; Zygosity=Heterozygous (from parent cell line).
Disease Colon carcinoma (NCIt: C4910)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0504 (RKO)
Sex of cell Sex unspecified
Age at sampling Age unspecified
Category Cancer cell line
Cross-references
Cell line collections (Providers) Horizon_Discovery; HD+106-022
Cell line databases/resources cancercelllines; CVCL_LD06
Encyclopedic resources Wikidata; Q54950543
Entry history
Entry creation22-Aug-2017
Last entry update19-Dec-2024
Version number12