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Cellosaurus WoWe (CVCL_LC74)

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Cell line name WoWe
Accession CVCL_LC74
Resource Identification Initiative To cite this cell line use: WoWe (RRID:CVCL_LC74)
Comments Doubling time: 7 days (PubMed=30873613).
Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Lower limb, skin; UBERON=UBERON_0003532.
Disease Merkel cell carcinoma (NCIt: C9231)
Cutaneous neuroendocrine carcinoma (ORDO: Orphanet_79140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 82Y
Category Cancer cell line
STR profile Source(s): PubMed=30873613

Markers:
AmelogeninX,Y
CSF1PO10
D3S135816
D5S81811
D7S8208,11
D8S117912,13
D13S3178,11
D16S53910,11
D18S5116,24
D21S1130,32
FGA21,25
Penta D12,13
Penta E12,16
TH017,9.3
TPOX8,11
vWA15,18

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Publications

PubMed=23563200; DOI=10.1038/jid.2013.169
Roland Houben, Christina Dreher, Sabrina Angermeyer, Andreas Borst, Jochen Sven Utikal, Sebastian Haferkamp, Wiebke K. Peitsch, David Schrama, Sonja Hesbacher;
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

PubMed=30873613; DOI=10.1002/ijc.32280
David Schrama, Eva-Maria Sarosi, Christian Adam, Cathrin Ritter, Ulrike Kaemmerer, Eva Klopocki, Eva-Maria Konig, Jochen Sven Utikal, Jurgen C. Becker, Roland Houben;
Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: integration pattern suggest that large T antigen truncating events occur before or during integration.
Int. J. Cancer 145:1020-1032(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_LC74
Encyclopedic resources Wikidata; Q54994368
Gene expression databases GEO; GSM1904848
Polymorphism and mutation databases Progenetix; CVCL_LC74
Entry history
Entry creation22-Aug-2017
Last entry update10-Apr-2025
Version number9