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Cellosaurus WoWe (CVCL_LC74)

[Text version]
Cell line name WoWe
Accession CVCL_LC74
Resource Identification Initiative To cite this cell line use: WoWe (RRID:CVCL_LC74)
Comments Doubling time: 7 days (PubMed=30873613).
Transformant: NCBI_TaxID; 493803; Merkel cell polyomavirus (MCPyV).
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Lower limb, skin; UBERON=UBERON_0003532.
Disease Merkel cell carcinoma (NCIt: C9231)
Cutaneous neuroendocrine carcinoma (ORDO: Orphanet_79140)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 82Y
Category Cancer cell line
STR profile Source(s): PubMed=30873613

Markers:
AmelogeninX,Y
CSF1PO10
D3S135816
D5S81811
D7S8208,11
D8S117912,13
D13S3178,11
D16S53910,11
D18S5116,24
D21S1130,32
FGA21,25
Penta D12,13
Penta E12,16
TH017,9.3
TPOX8,11
vWA15,18

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Publications

PubMed=23563200; DOI=10.1038/jid.2013.169
Houben R., Dreher C., Angermeyer S., Borst A., Utikal J.S., Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

PubMed=30873613; DOI=10.1002/ijc.32280
Schrama D., Sarosi E.-M., Adam C., Ritter C., Kaemmerer U., Klopocki E., Konig E.-M., Utikal J.S., Becker J.C., Houben R.
Characterization of six Merkel cell polyomavirus-positive Merkel cell carcinoma cell lines: integration pattern suggest that large T antigen truncating events occur before or during integration.
Int. J. Cancer 145:1020-1032(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_LC74
Encyclopedic resources Wikidata; Q54994368
Gene expression databases GEO; GSM1904848
Polymorphism and mutation databases Progenetix; CVCL_LC74
Entry history
Entry creation22-Aug-2017
Last entry update10-Apr-2025
Version number9