| Cell line name |
SF295 MX10 |
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| Accession |
CVCL_LB68 |
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| Resource Identification Initiative |
To cite this cell line use: SF295 MX10 (RRID:CVCL_LB68) |
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| Comments |
Population: Caucasian.
Characteristics: Resistant to 10 nM of mitoxantrone (PubMed=11559526).
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Derived from site: In situ; Brain, left temporal lobe; UBERON=UBERON_0002808. |
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| Sequence variations |
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Arg233Ter (c.697C>T); ClinVar=VCV000007813; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_1690 (SF295) |
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| Sex of cell |
Female |
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| Age at sampling |
67Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robert W. Robey, Yasumasa Honjo, Anne van de Laar, Keisuke Miyake, Joanna T. Regis, Thomas Litman, Susan E. Bates;
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001) PubMed=11559526
Yasumasa Honjo, Christine A. Hrycyna, Qing-Wu Yan, Wilma Y. Medina-Perez, Robert W. Robey, Anne van de Laar, Thomas Litman, Michael Dean, Susan E. Bates;
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Cancer Res. 61:6635-6639(2001) PubMed=12642696; DOI=10.4161/cbt.322
Yasumasa Honjo, Kuniaki Morisaki, Lyn Mickley Huff, Robert W. Robey, Jeffrey Hung, Michael Dean, Susan E. Bates;
Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1).
Cancer Biol. Ther. 1:696-702(2002) |
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| Cross-references |
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| Cell line collections (Providers) |
ABM; T8036
|
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| Cell line databases/resources |
cancercelllines; CVCL_LB68
|
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| Encyclopedic resources |
Wikidata; Q54952920
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| Entry history |
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| Entry creation | 22-Aug-2017 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 14 |
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