| Cell line name |
KM12 MX10 |
|---|
| Accession |
CVCL_LB66 |
|---|
| Resource Identification Initiative |
To cite this cell line use: KM12 MX10 (RRID:CVCL_LB66) |
|---|
| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
|---|
| Sequence variations |
- Gene fusion; HGNC; 8031; NTRK1 + HGNC; 12012; TPM3; Name(s)=TPM3-NTRK1 (from parent cell line).
- Mutation; HGNC; 173; ACVR2A; Simple; p.Lys437Argfs*5 (c.1310delA); dbSNP=rs764719749; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Asn1819fs*7 (c.5454_5455insA); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1101; BRCA2; Simple; p.Asn1784Hisfs*7 (c.5350_5351delAA); ClinVar=VCV000037959; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Gly129Ter (c.385G>T); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11773; TGFBR2; Simple; p.Lys128Serfs*35 (c.383delA); ClinVar=VCV000477546; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Val73Trpfs*50 (c.216delC) (p.P72fs); ClinVar=VCV000428897; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.His179Arg (c.536A>G); ClinVar=VCV000376606; Zygosity=Heterozygous (from parent cell line).
|
|---|
| Disease |
Colon carcinoma (NCIt: C4910) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_1331 (KM12) |
|---|
| Sex of cell |
Male |
|---|
| Age at sampling |
Age unspecified |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T., Litman T., Bates S.E.
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_LB66
|
|---|
| Encyclopedic resources |
Wikidata; Q54900053
|
|---|
| Entry history |
|---|
| Entry creation | 22-Aug-2017 |
|---|
| Last entry update | 05-Oct-2023 |
|---|
| Version number | 12 |
|---|
