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Cellosaurus 425 (CVCL_LB64)

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Cell line name 425
Synonyms MAb425; mAb 425; mAb425; EMD55900; EMD 55900
Accession CVCL_LB64
Resource Identification Initiative To cite this cell line use: 425 (RRID:CVCL_LB64)
Comments Group: Patented cell line.
Registration: International Depositary Authority, American Type Culture Collection (ATCC); HB-9629.
Biotechnology: The monoclonal antibody produced by this hybridoma was used to prepare the humanized matuzumab (EMD 72000) therapeutic antibody. It was developed by Merck Serono for the treatment of a number of cancer types. It failed phase II clinical trials.
Monoclonal antibody isotype: IgG2a.
Monoclonal antibody target: UniProtKB; P00533; Human EGFR.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Hierarchy Parent: CVCL_4032 (P3X63Ag8.653)
Category Hybridoma
Publications

PubMed=2434025; DOI=10.1016/0003-9861(87)90062-2
Uma Murthy, Aruna Basu, Ulrich Rodeck, Meenhard Herlyn, Alonzo H. Ross, Manjusri Das;
Binding of an antagonistic monoclonal antibody to an intact and fragmented EGF-receptor polypeptide.
Arch. Biochem. Biophys. 252:549-560(1987)

Patent=US5470571
Meenhard Herlyn, Ulrich Rodeck;
Method of treating human EGF receptor-expressing gliomas using radiolabeled EGF receptor-specific MAB 425.
Patent number US5470571, 28-Nov-1995

Cross-references
Cell line collections (Providers) ATCC; HB-9629
Encyclopedic resources Wikidata; Q54603012
Entry history
Entry creation22-Aug-2017
Last entry update21-Mar-2023
Version number5