| Cell line name |
MCF-7 MX100 |
|---|
| Synonyms |
MCF MX100 |
|---|
| Accession |
CVCL_LB54 |
|---|
| Resource Identification Initiative |
To cite this cell line use: MCF-7 MX100 (RRID:CVCL_LB54) |
|---|
| Comments |
Population: Caucasian.
Characteristics: Resistant to 100 nM of mitoxantrone (PubMed=15993268).
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
|---|
| Sequence variations |
- Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
|
|---|
| Disease |
Invasive breast carcinoma of no special type (NCIt: C4194) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_LB53 (MCF-7 MX80)
Children:
|
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
69Y |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robert W. Robey, Yasumasa Honjo, Anne van de Laar, Keisuke Miyake, Joanna T. Regis, Thomas Litman, Susan E. Bates;
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001) PubMed=11559526
Yasumasa Honjo, Christine A. Hrycyna, Qing-Wu Yan, Wilma Y. Medina-Perez, Robert W. Robey, Anne van de Laar, Thomas Litman, Michael Dean, Susan E. Bates;
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Cancer Res. 61:6635-6639(2001) PubMed=12642696; DOI=10.4161/cbt.322
Yasumasa Honjo, Kuniaki Morisaki, Lyn Mickley Huff, Robert W. Robey, Jeffrey Hung, Michael Dean, Susan E. Bates;
Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1).
Cancer Biol. Ther. 1:696-702(2002) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_LB54
|
|---|
| Encyclopedic resources |
Wikidata; Q54904318
|
|---|
| Entry history |
|---|
| Entry creation | 22-Aug-2017 |
|---|
| Last entry update | 10-Apr-2025 |
|---|
| Version number | 13 |
|---|
