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Cellosaurus MCF-7 MX100 (CVCL_LB54)

[Text version]
Cell line name MCF-7 MX100
Synonyms MCF MX100
Accession CVCL_LB54
Resource Identification Initiative To cite this cell line use: MCF-7 MX100 (RRID:CVCL_LB54)
Comments Population: Caucasian.
Characteristics: Resistant to 100 nM of mitoxantrone (PubMed=15993268).
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_LB53 (MCF-7 MX80)
Children:
CVCL_E5T3 (MCF-7 MX1000)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T., Litman T., Bates S.E.
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001)

PubMed=11559526
Honjo Y., Hrycyna C.A., Yan Q.-W., Medina-Perez W.Y., Robey R.W., van de Laar A., Litman T., Dean M., Bates S.E.
Acquired mutations in the MXR/BCRP/ABCP gene alter substrate specificity in MXR/BCRP/ABCP-overexpressing cells.
Cancer Res. 61:6635-6639(2001)

PubMed=12642696; DOI=10.4161/cbt.322
Honjo Y., Morisaki K., Huff L.M., Robey R.W., Hung J., Dean M., Bates S.E.
Single-nucleotide polymorphism (SNP) analysis in the ABC half-transporter ABCG2 (MXR/BCRP/ABCP1).
Cancer Biol. Ther. 1:696-702(2002)

Cross-references
Cell line databases/resources cancercelllines; CVCL_LB54
Encyclopedic resources Wikidata; Q54904318
Entry history
Entry creation22-Aug-2017
Last entry update10-Apr-2025
Version number13