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Cellosaurus MCF-7 MX40 (CVCL_LB52)

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Cell line name MCF-7 MX40
Accession CVCL_LB52
Resource Identification Initiative To cite this cell line use: MCF-7 MX40 (RRID:CVCL_LB52)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_50729; Mitoxantrone.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_LB51 (MCF-7 MX20)
Children:
CVCL_LB53 (MCF-7 MX80)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robert W. Robey, Yasumasa Honjo, Anne van de Laar, Keisuke Miyake, Joanna T. Regis, Thomas Litman, Susan E. Bates;
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_LB52
Encyclopedic resources Wikidata; Q54904320
Entry history
Entry creation22-Aug-2017
Last entry update19-Dec-2024
Version number12