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Cellosaurus PathHunter U2OS PRbeta Protein Interaction (CVCL_LB13)

[Text version]
Cell line name PathHunter U2OS PRbeta Protein Interaction
Accession CVCL_LB13
Resource Identification Initiative To cite this cell line use: PathHunter U2OS PRbeta Protein Interaction (RRID:CVCL_LB13)
Comments Population: Caucasian.
Characteristics: PathHunter NHR protein interaction cell lines co-express a NHR tagged with a beta-galactosidase fragment (ProLink=PK) and a receptor co-activator tagged with another fragment (Enzyme Acceptor=EA). Activation of the NHR results in co-activator-EA recruitment thus resulting into a catalytically active enzyme that generate a chemiluminescent signal.
Transfected with: HGNC; 8910; PGR (isoform B).
Transfected with: HGNC; 7671; NCOA4.
Derived from site: In situ; Bone, tibia; UBERON=UBERON_0000979.
Sequence variations
  • Mutation; HGNC; 9277; PPM1D; Simple; p.Arg458Ter (c.1372C>T); ClinVar=VCV002445214; Zygosity=Heterozygous (from parent cell line).
Disease Osteosarcoma (NCIt: C9145)
Osteosarcoma (ORDO: Orphanet_668)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0042 (U2OS)
Sex of cell Female
Age at sampling 15Y
Category Cancer cell line
Cell line collections (Providers) DiscoverX; 93-0851C3
Encyclopedic resources Wikidata; Q54938258
Entry history
Entry creation22-Aug-2017
Last entry update05-Oct-2023
Version number8