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Cellosaurus EndoC-betaH1 (CVCL_L909)

[Text version]
Cell line name EndoC-betaH1
Synonyms EndoC-BH1
Accession CVCL_L909
Resource Identification Initiative To cite this cell line use: EndoC-betaH1 (RRID:CVCL_L909)
Comments Characteristics: Secretes insulin in response to glucose challenge.
Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (PubMed=26901817).
Doubling time: 5 days (PubMed=21865645); 174 hours (PubMed=25803449).
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; ChIP-seq; H3K27me3.
Omics: Genomics; ChIP-seq; H3K36me3.
Omics: Genomics; ChIP-seq; H3K4me1.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Genomics; ChIP-seq; H3K79me2.
Omics: Genomics; ChIP-seq; H3K9me2.
Omics: Genomics; ChIP-seq; H3K9me3.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Miscellaneous: Sex assignment derived from omics analysis.
Derived from site: In situ; Fetal pancreas, islets of Langerhans; UBERON=UBERON_0000006.
Cell type: Pancreatic beta cell; CL=CL_0000169.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_YB06 (EndoC-betaH1 IDE-KO)CVCL_YB07 (EndoC-betaH1 INS-KO)CVCL_YB08 (EndoC-betaH1 NEUROD1-KO)
CVCL_YB09 (EndoC-betaH1 PAM-KO)CVCL_YB10 (EndoC-betaH1 SLC30A8-KO)
Sex of cell Female
Age at sampling 7-11FW
Category Transformed cell line
Web pages Provider; Human Cell Design; -; https://www.humancelldesign.com/endoc-bh1/
Publications

PubMed=21865645; DOI=10.1172/JCI58447; PMCID=PMC3163974
Philippe Ravassard, Yasmine Hazhouz, Severine Pechberty, Emilie Bricout-Neveu, Mathieu Armanet, Paul Czernichow, Raphael Scharfmann;
A genetically engineered human pancreatic beta cell line exhibiting glucose-inducible insulin secretion.
J. Clin. Invest. 121:3589-3597(2011)

PubMed=21865653; DOI=10.1172/JCI58899; PMCID=PMC3163975
Gordon C. Weir, Susan Bonner-Weir;
Finally! A human pancreatic beta cell line.
J. Clin. Invest. 121:3395-3397(2011)

PubMed=25803449; DOI=10.1371/journal.pone.0120879; PMCID=PMC4372368
Lotta E. Andersson, Berengere Valtat, Annika Bagge, Vladimir V. Sharoyko, David G. Nicholls, Philippe Ravassard, Raphael Scharfmann, Peter Spegel, Hindrik Mulder;
Characterization of stimulus-secretion coupling in the human pancreatic EndoC-betaH1 beta cell line.
PLoS ONE 10:e0120879.1-e0120879.18(2015)

PubMed=25822155; DOI=10.1097/MPA.0000000000000318
Kalaiselvan Krishnan, Zu-Heng Ma, Anneli Bjorklund, Mohammad Shahidul Islam;
Calcium signaling in a genetically engineered human pancreatic beta-cell line.
Pancreas 44:773-777(2015)

PubMed=26901817; DOI=10.1172/JCI83573; PMCID=PMC4767346
Jeannette Schlichting Kirkegaard, Philippe Ravassard, Signe Ziir Ingvarsen, Marc Diedisheim, Emilie Bricout-Neveu, Mads Gronborg, Thomas Frogne, Raphael Scharfmann, Ole D. Madsen, Claude Rescan, Olivier Albagli-Curiel;
Xenotropic retrovirus Bxv1 in human pancreatic beta cell lines.
J. Clin. Invest. 126:1109-1113(2016)

PubMed=29307512; DOI=10.1016/j.molmet.2017.12.007; PMCID=PMC5985049
Violeta Georgieva Tsonkova, Fredrik Wolfhagen Sand, Xenia Asbaek Wolf, Lars Groth Grunnet, Anna Kirstine Ringgaard, Camilla Ingvorsen, Louise Winkel, Mark Kalisz, Kevin Dalgaard, Christine Bruun, Johannes Josef Fels, Charlotte Helgstrand, Sven Hastrup ...Show all 36 authors... , Fredrik Kryh Oberg, Erik Vernet, Michael Paolo Bastner Sandrini, Allan Christian Shaw, Carsten Jessen, Mads Gronborg, Jacob Hald, Hanni Willenbrock, Dennis Madsen, Rasmus Wernersson, Lena Hansson, Jan Nygaard Jensen, Annette Plesner, Tomas Alanentalo, Maja Borup Kjaer Petersen, Anne Grapin-Botton, Christian Honore, Jonas Ahnfelt-Ronne, Jacob Hecksher-Sorensen, Philippe Ravassard, Ole D. Madsen, Claude Rescan, Thomas Frogne; Show fewer authors
The EndoC-betaH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates.
Mol. Metab. 8:144-157(2018)

PubMed=30251567; DOI=10.1177/0963689718798564; PMCID=PMC6180725
Silvia Pellegrini, Fabio Manenti, Raniero Chimienti, Rita Nano, Linda Ottoboni, Francesca Ruffini, Gianvito Martino, Philippe Ravassard, Lorenzo Piemonti, Valeria Sordi;
Differentiation of Sendai virus-reprogrammed iPSC into beta cells, compared with human pancreatic islets and immortalized beta cell line.
Cell Transplant. 27:1548-1560(2018)

PubMed=31976379; DOI=10.12688/wellcomeopenres.15447.2; PMCID=PMC6961417
Antje Kristin Grotz, Fernando Abaitua, Elena Navarro-Guerrero, Benoit Hastoy, Daniel Ebner, Anna L. Gloyn;
A CRISPR/Cas9 genome editing pipeline in the EndoC-betaH1 cell line to study genes implicated in beta cell function.
Wellcome Open Res. 4:150-150(2019)

Cross-references
Encyclopedic resources Wikidata; Q54832322
Gene expression databases GEO; GSE118588
GEO; GSM7029168
GEO; GSM7029169
GEO; GSM7029170
GEO; GSM7029171
GEO; GSM7029172
Proteomic databases PRIDE; PXD027920
Entry history
Entry creation06-May-2013
Last entry update14-Aug-2025
Version number25