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Cellosaurus VU-SCC-147 (CVCL_L895)

[Text version]
Cell line name VU-SCC-147
Synonyms 93-VU-147T; 93VU-147T; 93VU147T; 147T
Accession CVCL_L895
Resource Identification Initiative To cite this cell line use: VU-SCC-147 (RRID:CVCL_L895)
Comments Part of: OPC-22 oral and pharyngeal cancer cell line panel.
Doubling time: 2.2 days (PubMed=29156801).
Karyotypic information: Has lost chromosome Y.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing; Low read coverage.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; RNAseq.
Misspelling: 93YU47; Cosmic=1530733.
Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
Sequence variations
Disease Floor of mouth squamous cell carcinoma (NCIt: C4041)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): PubMed=25275298; PubMed=29156801; PubMed=33802339

Markers:
AmelogeninX
CSF1PO11,12
D2S133820,24
D3S135815,17
D5S81811,12
D7S82010,11
D8S117913,15
D13S31712
D16S5399,11
D18S5116
D19S43314,15
D21S1130,31 (PubMed=25275298)
31 (PubMed=33802339)
FGA22
Penta D12,13.4
Penta E11,12
TH017,9
TPOX9,11
vWA18

Run an STR similarity search on this cell line
Web pages Provider; AHNS; -; https://www.ahns.info/view/research-cell-lines-view/entry/24336/
Publications

PubMed=7585617
Renske D.M. Steenbergen, Mario A.J.A. Hermsen, Jan M.M. Walboomers, Hans Joenje, Fre Arwert, Chris J.L.M. Meijer, Peter J.F. Snijders;
Integrated human papillomavirus type 16 and loss of heterozygosity at 11q22 and 18q21 in an oral carcinoma and its derivative cell line.
Cancer Res. 55:5465-5471(1995)

PubMed=8824719; DOI=10.1002/(SICI)1098-2264(199601)15:1<1::AID-GCC1>3.0.CO;2-8
Mario A.J.A. Hermsen, Hans Joenje, Fre Arwert, Marij J.P. Welters, Boudewijn J.M. Braakhuis, Marian Bagnay, Andries Westerveld, Rosalyn M. Slater;
Centromeric breakage as a major cause of cytogenetic abnormalities in oral squamous cell carcinoma.
Genes Chromosomes Cancer 15:1-9(1996)

PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082
Wendell Gray Yarbrough, Amy Whigham, Brandee Brown, Michael Roach, Robbert J.C. Slebos;
Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas.
Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007)

PubMed=23419152; DOI=10.1186/gm419; PMCID=PMC3706778
Matthias Lechner, Tim R. Fenton, James West, Gareth Wilson, Andrew Feber, Stephen Henderson, Christina Thirlwell, Harpreet K. Dibra, Amrita Jay, Lee M. Butcher, Ankur Ravinarayana Chakravarthy ...Show all 19 authors... , Fiona Gratrix, Nirali Patel, Francis Vaz, Paul O'Flynn, Nicholas Kalavrezos, Andrew Erich Teschendorff, Chris Boshoff, Stephan Beck; Show fewer authors
Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma.
Genome Med. 5:15.1-15.16(2013)

PubMed=23613873; DOI=10.1371/journal.pone.0061555; PMCID=PMC3629194
Sanne R. Martens-de Kemp, Simone U. Dalm, Fiona M.J. Wijnolts, Arjen Brink, Richard J. Honeywell, Godefridus Johannes Peters, Boudewijn J.M. Braakhuis, Ruud H. Brakenhoff;
DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells.
PLoS ONE 8:e61555.1-e61555.9(2013)

PubMed=25275298; DOI=10.18632/oncotarget.2417; PMCID=PMC4253406
Daniel Martin, Martin C. Abba, Alfredo Alberto Molinolo, Lynn Vitale-Cross, Zhi-Yong Wang, Moraima Zaida, Naomi C. Delic, Yardena Samuels, J. Guy Lyons, J. Silvio Gutkind;
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Oncotarget 5:8906-8923(2014)

PubMed=26045983; PMCID=PMC4449432
Frank Ziemann, Andrea Arenz, Stefanie Preising, Claus Wittekindt, Jens Peter Klussmann, Rita Engenhart-Cabillic, Andrea Wittig;
Increased sensitivity of HPV-positive head and neck cancer cell lines to X-irradiation +/- cisplatin due to decreased expression of E6 and E7 oncoproteins and enhanced apoptosis.
Am. J. Cancer Res. 5:1017-1031(2015)

PubMed=26122845; DOI=10.1158/0008-5472.CAN-15-0528
Chantal Stoepker, Najim Ameziane, Petra van der Lelij, Irsan E. Kooi, Anneke B. Oostra, Martin A. Rooimans, Saskia E. van Mil, Arjen Brink, Ralf Dietrich, Jesper A. Balk, Bauke Ylstra ...Show all 14 authors... , Hans Joenje, Stephan M. Feller, Ruud H. Brakenhoff; Show fewer authors
Defects in the Fanconi anemia pathway and chromatid cohesion in head and neck cancer.
Cancer Res. 75:3543-3553(2015)

PubMed=28236344; DOI=10.1002/hed.24729; PMCID=PMC5392184
Heather M. Walline, Christine Marie Goudsmit, Jonathan B. McHugh, Alice L. Tang, John Henry Owen, Bin Tean Teh, Erin L. McKean, Thomas W. Glover, Martin P. Graham, Mark Edward P. Prince, Douglas Brian Chepeha ...Show all 19 authors... , Steven B. Chinn, Robert Louis Ferris, Susanne M. Gollin, Thomas K. Hoffmann, Henning Bier, Ruud H. Brakenhoff, Carol R. Bradford, Thomas E. Carey; Show fewer authors
University of Michigan Head and Neck Specialized Program of Research Excellence (SPORE) Program
Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines.
Head Neck 39:840-852(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691
Nene N. Kalu, Tuhina Mazumdar, Shao-Hua Peng, Li Shen, Vaishnav Sambandam, Xia-Yu Rao, Yuan-Xin Xi, Le-Rong Li, Yuan Qi, Frederico O. Gleber-Netto, Ameeta Patel ...Show all 16 authors... , Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering, Faye M. Johnson; Show fewer authors
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

PubMed=31541927; DOI=10.1016/j.oraloncology.2019.09.004; PMCID=PMC7372097
Anne M. van Harten, Jos B. Poell, Marijke Buijze, Arjen Brink, Susanne I. Wells, C. Rene Leemans, Rob M.F. Wolthuis, Ruud H. Brakenhoff;
Characterization of a head and neck cancer-derived cell line panel confirms the distinct TP53-proficient copy number-silent subclass.
Oral Oncol. 98:53-61(2019)

PubMed=33802339; DOI=10.3390/cancers13051069; PMCID=PMC7959143
Eva-Leonne Gottgens, Marleen Ansems, William P.J. Leenders, Johan Bussink, Paul N. Span;
Genotyping and characterization of HPV status, hypoxia, and radiosensitivity in 22 head and neck cancer cell lines.
Cancers (Basel) 13:1069.1-1069.12(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_L895
Encyclopedic resources Wikidata; Q54993383
Gene expression databases GEO; GSM937834
GEO; GSM937835
Polymorphism and mutation databases Cosmic; 1122678
Cosmic; 1530733
Cosmic; 2296308
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number22